High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models

High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models

Item
http://www.wikidata.org/entity/Q28486219
Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugsContemporary murine models in preclinical astrocytoma drug developmentModelling mutational landscapes of human cancers in vitro.In silico modeling predicts drug sensitivity of patient-derived cancer cells.Protein domain-level landscape of cancer-type-specific somatic mutations.Whole exome sequencing of a single osteosarcoma case--integrative analysis with whole transcriptome RNA-seq data.High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile.Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.Astrocytoma-associated antigens - IL13Rα2, Fra-1, and EphA2 as potential markers to monitor the status of tumour-derived cell cultures in vitro.Extrachromosomal driver mutations in glioblastoma and low-grade glioma.Personalized medicine in neuro-oncology.
P2860

High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models

Item
http://www.wikidata.org/entity/Q28486219
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
High-resolution mutational pro ...... nt-derived pre-clinical models
@ast
High-resolution mutational pro ...... nt-derived pre-clinical models
@en
High-resolution mutational pro ...... nt-derived pre-clinical models
@nl
type
label
High-resolution mutational pro ...... nt-derived pre-clinical models
@ast
High-resolution mutational pro ...... nt-derived pre-clinical models
@en
High-resolution mutational pro ...... nt-derived pre-clinical models
@nl
prefLabel
High-resolution mutational pro ...... nt-derived pre-clinical models
@ast
High-resolution mutational pro ...... nt-derived pre-clinical models
@en
High-resolution mutational pro ...... nt-derived pre-clinical models
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
High-resolution mutational pro ...... nt-derived pre-clinical models
@en
P2093
P2860
P304
P31
P356
10.1371/JOURNAL.PONE.0056185
P407
P433
P478
P50
P577
P5875
P698
P921
P932