Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms
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Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma bruceiThe Open Form Inducer Approach for Structure-Based Drug Design.Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels.The role of the de novo pyrimidine biosynthetic pathway in Cryptococcus neoformans high temperature growth and virulence.Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucoseHomoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Fresh insights into the pyrimidine metabolism in the trypanosomatids.
P2860
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P2860
Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms
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name
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@ast
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@en
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@nl
type
label
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@ast
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@en
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@nl
prefLabel
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@ast
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@en
Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
@nl
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P50
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Pyrimidine biosynthesis is not ...... osoma brucei bloodstream forms
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Anne Donachie
Juma A M Ali
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P3181
P356
10.1371/JOURNAL.PONE.0058034
P407
P577
2013-01-01T00:00:00Z