Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment
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FVIII inhibitors: pathogenesis and avoidanceRecent Advances in Application of Pharmacogenomics for BiotherapeuticsEndogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia AAdvancing Public Health Using Regulatory Science to Enhance Development and Regulation of Medical Products: Food and Drug Administration Research at the Center for Biologics Evaluation and ResearchThe intron-22-inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomicsA large-scale computational study of inhibitor risk in non-severe haemophilia A.Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B.Computational modelling and inhibitor risk: predicting the future?Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools.Immunogenicity assessment during the development of protein therapeutics.Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins.
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P2860
Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment
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2013年の論文
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2013年論文
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2013年論文
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Polymorphisms in the F8 gene a ...... a: a computational assessment
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Polymorphisms in the F8 gene a ...... a: a computational assessment
@en
Polymorphisms in the F8 gene a ...... a: a computational assessment
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Polymorphisms in the F8 gene a ...... a: a computational assessment
@ast
Polymorphisms in the F8 gene a ...... a: a computational assessment
@en
Polymorphisms in the F8 gene a ...... a: a computational assessment
@nl
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Polymorphisms in the F8 gene a ...... a: a computational assessment
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Polymorphisms in the F8 gene a ...... a: a computational assessment
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Polymorphisms in the F8 gene a ...... a: a computational assessment
@nl
P2093
P2860
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Polymorphisms in the F8 gene a ...... a: a computational assessment
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P2093
Gouri Shankar Pandey
Tom E Howard
Zuben E Sauna
P2860
P304
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10.1371/JOURNAL.PCBI.1003066
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P50
P577
2013-01-01T00:00:00Z