TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
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TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKLNegative regulation of protein phosphatase 2Cbeta by ISG15 conjugationPhosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathwaysRetroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKKThe MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokinesProtein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathwayHaploinsufficiency of TAB2 causes congenital heart defects in humansModulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold proteinHSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathwayTAK1-dependent signaling requires functional interaction with TAB2/TAB3Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expresEssential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signalingVaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activationTRIM family proteins and their emerging roles in innate immunityAblation of TAK1 upregulates reactive oxygen species and selectively kills tumor cellsTNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathwayPathogen recognition and inflammatory signaling in innate immune defensesRegulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healingFunction of Nod-like receptors in microbial recognition and host defenseRegulation of cell proliferation and migration by TAK1 via transcriptional control of von Hippel-Lindau tumor suppressor.A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activationPellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activationInterleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinaseEffect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activationTAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosisOsmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathwaysUbiquitin signaling in immune responsesMolecular Mechanisms Underlying Peritoneal EMT and FibrosisSmad3 phospho-isoform signaling in hepatitis C virus-related chronic liver diseasesThe TLR and IL-1 signalling network at a glanceRole of TGFβ in regulation of the tumor microenvironment and drug delivery (review)TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and MetastasisTransforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermisRegulation of tumour necrosis factor signalling: live or let dieNF-kappaB and the immune responseRIP1, a kinase on the crossroads of a cell's decision to live or dieRIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibitionBasic principles and emerging concepts in the redox control of transcription factorsReactive oxygen species, cellular redox systems, and apoptosis
P2860
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P248
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P2860
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
TAK1, but not TAB1 or TAB2, pl ...... ple signaling pathways in vivo
@nl
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@ast
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@en
type
label
TAK1, but not TAB1 or TAB2, pl ...... ple signaling pathways in vivo
@nl
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@ast
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@en
prefLabel
TAK1, but not TAB1 or TAB2, pl ...... ple signaling pathways in vivo
@nl
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@ast
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@en
P2093
P2860
P921
P3181
P356
P1433
P1476
TAK1, but not TAB1 or TAB2, pl ...... le signaling pathways in vivo.
@en
P2093
Amber E Paschal
Changchun Xiao
Crystal Bussey
Gen Yamada
Jae-Hyuck Shim
Ki-Young Lee
Kunihiro Matsumoto
Matthew S Hayden
Michael Steckel
Nobuyuki Tanaka
P2860
P304
P3181
P356
10.1101/GAD.1360605
P577
2005-10-31T00:00:00Z