Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.
about
Mitochondrial genome changes and neurodegenerative diseasesNucleotide salvage deficiencies, DNA damage and neurodegenerationFoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in miceThymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in miceDeoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.Defects in mitochondrial DNA replication and human diseaseOnset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressZidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells.Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidationInsights into the pathogenesis and treatment of cancer from inborn errors of metabolism.Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice.Heart mitochondrial TTP synthesis and the compartmentalization of TMP.Mitochondrial DNA mutations in disease and agingInhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cellsMitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancerThe mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasisMouse models of mitochondrial DNA defects and their relevance for human disease.Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.Mouse models of oxidative phosphorylation dysfunction and diseaseTwo transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterationsScreen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies.The clinical maze of mitochondrial neurologyDevelopment of pharmacological strategies for mitochondrial disorders.Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review.Mitochondrial transcription: lessons from mouse models.Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes.Quantitation of cellular deoxynucleoside triphosphates.Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.Fishing in the (deoxyribonucleotide) pool.Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency.Mitochondrial dysfunction and ovarian aging.
P2860
Q27023750-803A75BB-5097-496F-8BC0-DE2D04A4E8EFQ28081515-044D257A-36DE-4361-ACE1-DEC4270496EEQ33559637-E9C55549-78AF-4E3F-8459-D4581E5C2554Q34117877-7533A9B7-F733-47FD-88FA-C64E93CC9B60Q34131169-EB5F53F9-0DD9-4AD3-904C-5A4EC7C77BCDQ34241192-7D052025-0BF2-4DEF-9355-3B436F2CCC58Q34399422-C50ADDF9-7D30-45FD-8E7D-B94685294C93Q34401495-121D9527-05D7-4E28-BB62-A256C4BC07F8Q34406171-A6A06294-3094-4C8E-96FF-DF8921F1910CQ34436535-3986F166-F14B-4C8B-B339-94DB2255DA7EQ34558619-9CDADEA4-4199-4943-BD00-252EB82A7B7BQ34626065-A17D9BBB-F4D3-481F-88F7-2C136820FBD2Q34768395-801C2858-CB5A-4A08-AE79-8A35E8A4C1A6Q34837616-87696ACA-8F5A-4C7D-8212-F411C195D61AQ35002808-41EE4EFC-6AC9-4C79-846E-E77799187F83Q35018267-4DD19DD8-0A16-439E-B3B3-48F69AB4B41AQ35038005-B4F2E559-93C5-4859-8151-6468B9ADD168Q35535022-CCF13285-A838-4FAE-AD3A-F658D82E8CE0Q35660977-A71CCC16-830D-40F7-A3E4-341BC0CACBC4Q35893619-98EA0A06-861D-4411-9FE8-9D17F6AE6CC6Q36394649-CE8B9CFA-A3EA-43BF-9E8F-69CD9C65DD45Q36783448-CADDAC61-E4F0-44FD-9E6D-D2DB7F9BA557Q37087221-6F5C118C-6FB6-4570-A577-7EE469A7F74CQ37094802-8D6FA38E-F7E0-414F-A959-8C7222E21DDBQ37120825-BBED3EF5-D2E9-4F01-8E99-653FF00C12DEQ37449919-9DC77352-C5D3-41F2-ACBE-BA70D899AA3FQ37566132-4DBE27C0-D1C6-46D8-9270-FBDB1B17D825Q37607682-07261C5D-BB82-487B-9167-77F586268FE7Q37648911-0BF56286-FB5D-473C-B9C6-9B3C0CD36416Q37686237-77F25C75-7E89-45C9-93C6-A65C5C5978A0Q37764763-39DBFD55-8072-4FEA-BF09-517B6B5A2882Q37961478-DDA31D36-B1A1-4066-AA1A-909359C55E30Q39214553-A5664FFB-5541-49F8-9FC8-EBEE36DABEA1Q39843396-1F54A528-2B58-4471-BC92-14DF6B8A30D1Q39927495-B58FEC20-6578-489A-A27E-AFA69531BFE9Q43026538-4E785B0F-E7EC-498A-A85B-0B869F6F4B52Q43288107-30A52862-6E25-423F-B415-C38A9B9FFD20Q46156686-9B5320E4-C1D4-4A29-A75F-BD8D82245503Q47945459-C178A396-8B44-44D6-89B9-719F085C256FQ48047379-AB8A8B8F-76CF-4C95-B71F-F560C891C4DD
P2860
Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance
@nl
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@ast
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@en
type
label
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance
@nl
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@ast
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@en
prefLabel
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance
@nl
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@ast
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance.
@en
P2093
P2860
P50
P3181
P356
P1476
Thymidine kinase 2 (H126N) kno ...... mitochondrial DNA maintenance
@en
P2093
Angeles García-Cazorla
Beatriz Dorado
Eduardo Bonilla
Hasan O Akman
Kurenai Tanji
Maya R Vilà
Michio Hirano
P2860
P304
P3181
P356
10.1093/HMG/DDN143
P577
2008-05-08T00:00:00Z