A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
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Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase HeterodimerHuman cytomegalovirus UL18 utilizes US6 for evading the NK and T-cell responsesModes of calreticulin recruitment to the major histocompatibility complex class I assembly pathwayMechanisms of function of tapasin, a critical major histocompatibility complex class I assembly factorDistinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Direct peptide-regulatable interactions between MHC class I molecules and tapasin.Newly discovered viral E3 ligase pK3 induces endoplasmic reticulum-associated degradation of class I major histocompatibility proteins and their membrane-bound chaperonesTapasin and other chaperones: models of the MHC class I loading complex.Dynamics of major histocompatibility complex class I association with the human peptide-loading complex.Accessory molecules in the assembly of major histocompatibility complex class I/peptide complexes: how essential are they for CD8(+) T-cell immune responses?Mechanisms of MHC class I-restricted antigen processing and cross-presentation.Functional significance of tapasin membrane association and disulfide linkage to ERp57 in MHC class I presentationAntigen presentation machinery (APM) modulation and soluble HLA molecules in the tumor microenvironment: do they provide tumor cells with escape mechanisms from recognition by cytotoxic T lymphocytes?ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.Viral proteins interfering with antigen presentation target the major histocompatibility complex class I peptide-loading complex.MHC class I assembly: out and about.The quality control of MHC class I peptide loading.Intracellular assembly and trafficking of MHC class I molecules.Cowpox virus inhibits the transporter associated with antigen processing to evade T cell recognition.The peptide-loading complex--antigen translocation and MHC class I loading.The TAP translocation machinery in adaptive immunity and viral escape mechanisms.Understanding the obstacle of incompatibility at residue 156 within HLA-B*35 subtypes.F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins.Three tapasin docking sites in TAP cooperate to facilitate transporter stabilization and heterodimerization.Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.Influence of the tapasin C terminus on the assembly of MHC class I allotypes.Differential contribution of TAP and tapasin to HLA class I antigen expression.Aggregate formation by ERp57-deficient MHC class I peptide-loading complexes.Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit.Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP).A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule.In vitro reconstitution of the MHC class I peptide-loading complex.The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide.A natural tapasin isoform lacking exon 3 modifies peptide loading complex function.Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.Stoichiometric tapasin interactions in the catalysis of major histocompatibility complex class I molecule assembly.
P2860
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P2860
A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression
description
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Januar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/01/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/01/01)
@nl
наукова стаття, опублікована в січні 2003
@uk
مقالة علمية (نشرت عام 2003)
@ar
name
A major role for tapasin as a ...... ces for MHC class I expression
@ast
A major role for tapasin as a ...... ces for MHC class I expression
@en
A major role for tapasin as a ...... ces for MHC class I expression
@nl
type
label
A major role for tapasin as a ...... ces for MHC class I expression
@ast
A major role for tapasin as a ...... ces for MHC class I expression
@en
A major role for tapasin as a ...... ces for MHC class I expression
@nl
prefLabel
A major role for tapasin as a ...... ces for MHC class I expression
@ast
A major role for tapasin as a ...... ces for MHC class I expression
@en
A major role for tapasin as a ...... ces for MHC class I expression
@nl
P2093
P356
P1476
A major role for tapasin as a ...... ces for MHC class I expression
@en
P2093
Frank Momburg
Günter J. Hämmerling
Natalio Garbi
Neeraj Tiwari
P304
P356
10.1002/IMMU.200390029
P407
P577
2003-01-01T00:00:00Z