Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
about
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityA Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease PathogenesisThe endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive diseaseExtra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disordersMechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disordersEarly postnatal in vivo gliogenesis from nestin-lineage progenitors requires cdk5Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.Vitamin D and differentiation in cancer.The evolutionary young miR-1290 favors mitotic exit and differentiation of human neural progenitors through altering the cell cycle proteins.Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesisCdk5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation.Molecular mechanisms of neurodegeneration in Alzheimer's disease.Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach.Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.ATM and the epigenetics of the neuronal genome.MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin.CDK5 activator protein p25 preferentially binds and activates GSK3βCDK5 is a major regulator of the tumor suppressor DLC1Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.Zebrafish Rohon-Beard neuron development: cdk5 in the midst.Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease.Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex.The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiationCyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsThe roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons.Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of CortiCyclin-dependent kinase 5 is required for normal cerebellar developmentCyclin-dependent kinase 5 in synaptic plasticity, learning and memory.The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and MyelinationCell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons.Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease.Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.
P2860
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P2860
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
description
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Oktober 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/10/19)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/10/19)
@nl
наукова стаття, опублікована в жовтні 2005
@uk
مقالة علمية (نشرت في 19-10-2005)
@ar
name
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@ast
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@en
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@nl
type
label
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@ast
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@en
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@nl
prefLabel
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@ast
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@en
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@nl
P3181
P1476
Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation
@en
P2093
Karl Herrup
Samantha Cicero
P304
P3181
P356
10.1523/JNEUROSCI.1773-05.2005
P407
P577
2005-10-19T00:00:00Z