Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
about
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6DNA replication fidelity and cancerElevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epitheliumApplication of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis.Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.Just how does the cII selection system work in Muta Mouse?Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegansAlkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.Human postmeiotic segregation 2 exhibits biased repair at tetranucleotide microsatellite sequencesDNA repair dysfunction in gastrointestinal tract cancers.Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells.A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolutionMutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum.Single-cell immunohistochemical mutation load assay (SCIMLA) using human paraffin-embedded tissues.Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
P2860
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P2860
Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts
description
2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Juli 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/07/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/07/01)
@nl
наукова стаття, опублікована в липні 2000
@uk
مقالة علمية (نشرت في يوليو 2000)
@ar
name
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@ast
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@en
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@nl
type
label
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@ast
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@en
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@nl
prefLabel
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@ast
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@en
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@nl
P2093
P2860
P356
P1433
P1476
Mutagenesis in PMS2- and MSH2- ...... transversions and frameshifts
@en
P2093
A. Baross-Francis
F. R. Jirik
K. Milhausen
L. Narayanan
P. M. Glazer
R. M. Liskay
S. E. Andrew
P2860
P304
P356
10.1093/CARCIN/21.7.1291
P407
P577
2000-07-01T00:00:00Z