Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
about
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer TherapyNew insights in bilirubin metabolism and their clinical implicationsComplete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liverFunctional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate.Bile formation and secretion.Quantitative assessment of the multiple processes responsible for bilirubin homeostasis in health and disease.The SLCO (former SLC21) superfamily of transporters.Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.Targeting TNF-α and NF-κB activation by bee venom: role in suppressing adjuvant induced arthritis and methotrexate hepatotoxicity in rats.Intestinal transport and metabolism of bile acidsContribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearanceDifferences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C.Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate dispositionHepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injuryProteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in LiverGrowth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism.Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.What do drug transporters really do?Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronideA phosphotyrosine switch regulates organic cation transporters.Modulation of OATP1B-type transporter function alters cellular uptake and disposition of platinum chemotherapeutics.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Organic anion uptake by hepatocytes.Organic anion-transporting polypeptide 1a4 (Oatp1a4) is important for secondary bile acid metabolism.Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes.Pharmacokinetic and pharmacogenetic determinants and considerations in chemotherapy selection and dosing in infants.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions.Bile Acid Uptake Transporters as Targets for Therapy.Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.
P2860
Q26829894-2D0F3FCA-0B16-444D-A59A-B7751DD84A4AQ26863145-42DD809E-95A5-4576-A625-641011F9ED02Q28257094-46DB5791-F84F-4CFD-BBD7-B14600FAA71AQ30367871-A61A0A01-4E29-4779-992F-638487E8F94AQ33881922-0853E8A3-EAA9-4071-B7D5-33E5790EA399Q34155271-E1248416-E39D-4758-AD7E-012E2BCC26B3Q34333710-F621F4E1-1DAF-4231-9BEC-4D76665F6126Q34382931-2555DD15-49C6-4009-8D58-070723B92FC1Q34395323-D5B2805C-083B-4EA9-BB56-0BB53F0046AFQ35053154-CE23BC7E-01C7-493F-B3ED-1A8E32A4178EQ35247159-987CE83D-8214-4B34-A229-9A6277E82F4EQ35375045-2679522B-2691-4440-864A-8ACA96BC4C56Q35579547-53D4BF15-62ED-4746-A8F6-D2205BD89908Q35634476-25927B0E-AC39-4731-B1BB-E92323DE7ECFQ35812091-7136C74D-CA70-4EE8-B1C5-96F0DE9A7FC4Q35969305-479792CA-1736-4DF1-A653-4EA426AD2EF6Q36062197-84633CC3-4AA6-49F8-87EB-5302A57C770CQ36189092-B843FBC2-8C53-46EB-AADC-447751F97336Q36291395-D97821C2-75DC-4562-B55A-9DC82D57896DQ36311265-D3E7614D-5B8A-4F77-BE97-87FE527A7AE3Q36571217-2257A4ED-FCE7-405B-9564-7B2F2E44EB38Q36698681-548537F2-0B04-463B-BE03-382E6F5BC8DDQ36704820-B2000AB9-5B4C-40C5-85D7-F567B0CDA339Q37093336-F0706238-D0DF-42C5-8A0C-0AABD99B4789Q37121662-24E24257-18EC-4447-B777-DBBE4E074533Q37137527-EECDCC95-D85F-4BBD-9F92-91D4DF3E19E7Q37174462-90E12B9D-DC05-4ED2-88DC-3ED36D204F6DQ37439697-35B8DF5F-6DBC-4482-BA78-BA71C13A8E71Q37504548-1F20AAFF-98FF-441F-9507-098364DF90C6Q37606997-7E0145C4-8E26-45A1-8F7B-23FD6A440DB6Q38003177-4A5E1307-5201-409C-94E5-1999B0EEC41DQ38120833-21FAE485-0108-47F3-8475-75E37D775178Q38214334-E0704E10-7312-482E-97B1-5D4A43D6F52AQ38255685-C081574F-CB62-4629-BBD0-63EEDAF733CBQ38737388-AD62BDF6-4CF9-4C66-8C07-633A86710B8CQ38962542-5122B5FB-B3FB-4C82-B6BB-CDD6894239D3Q38991373-3EE07CA1-2B8F-4E42-B4F7-C4F9402D503BQ39156569-1518A088-8C79-4181-9744-845EF9FDBFE5Q40215280-F6AA532D-16A4-4DB6-8CB9-01265B3C9DDDQ41647064-29B81FEC-37DE-4854-8217-DB88ABB8B1B2
P2860
Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
description
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im August 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/08/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/08/01)
@nl
наукова стаття, опублікована в серпні 2010
@uk
مقالة علمية (نشرت في أغسطس 2010)
@ar
name
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@ast
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@en
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@nl
type
label
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@ast
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@en
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@nl
prefLabel
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@ast
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@en
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@nl
P2093
P2860
P3181
P356
P1476
Organic anion transporting pol ...... lirubin, bile acids, and drugs
@en
P2093
Alfred H. Schinkel
Cornelia M. M. van der Kruijssen
Dirk R. de Waart
Els Wagenaar
Evita van de Steeg
Johanna E. C. Burggraaff
Kathryn E. Kenworthy
Ronald P. J. Oude Elferink
P2860
P304
P3181
P356
10.1172/JCI42168
P407
P577
2010-08-01T00:00:00Z