Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
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A positive role of microRNA-15b on regulation of osteoblast differentiation.Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region.Nkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcriptionInterplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells.The Role of RUNX2 in Osteosarcoma Oncogenesis.Runx1 Activities in Superficial Zone Chondrocytes, Osteoarthritic Chondrocyte Clones and Response to Mechanical Loading.Strategies to minimize hypertrophy in cartilage engineering and regeneration.Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation.HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in miceMultifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineeringMicroRNA control of bone formation and homeostasis.Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 geneRole of LRF/Pokemon in lineage fate decisions.The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors.A gradient of Shh establishes mutually repressing somitic cell fates induced by Nkx3.2 and Pax3.Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.SWI/SNF-independent nuclease hypersensitivity and an increased level of histone acetylation at the P1 promoter accompany active transcription of the bone master gene Runx2.Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.Controlling stem cell-mediated bone regeneration through tailored mechanical properties of collagen scaffoldsDifferentiation of mesenchymal stem cells to osteoblasts and chondrocytes: a focus on adenosine receptors.Articular cartilage tissue engineering: the role of signaling molecules.Ethanol Extract of Cissus quadrangularis Enhances Osteoblast Differentiation and Mineralization of Murine Pre-Osteoblastic MC3T3-E1 Cells.Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells.Transcriptional regulation of cGMP-dependent protein kinase II (cGK-II) in chondrocytes.Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.Transcriptional regulation by RUNX2Regulation of RUNX2 expression and activityHMGB proteins and arthritis.NKX3-2 binds RUNX2 gene promoterRUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2; MSX2 and RUNX2-P1; and stimulated by DLX5;(DLX6)Cartilage-Specific and Cre-Dependent Nkx3.2 Overexpression In Vivo Causes Skeletal Dwarfism by Delaying Cartilage Hypertrophy.An evo-devo view on the origin of the backbone: evolutionary development of the vertebrae.Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation.BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
P2860
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P2860
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
description
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im April 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/04/22)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/04/22)
@nl
наукова стаття, опублікована у квітні 2005
@uk
name
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@ast
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@en
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@nl
type
label
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@ast
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@en
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@nl
prefLabel
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@ast
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@en
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@nl
P2093
P2860
P356
P1476
Nkx3.2-mediated repression of Runx2 promotes chondrogenic differentiation
@en
P2093
Andre J van Wijnen
Christoph Lepper
Gary S Stein
Jane B Lian
Janet L Stein
Mohammad Q Hassan
Ryan W Serra
P2860
P304
15872-15879
P356
10.1074/JBC.M411144200
P407
P577
2005-02-08T00:00:00Z