Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
about
β-Cell MicroRNAs: Small but PowerfulHDL and glucose metabolism: current evidence and therapeutic potentialNuclear receptors as drug targets for metabolic disease.Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate.Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.Lipoproteins and β-Cell Functions: From Basic to Clinical Data.The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.An islet in distress: β cell failure in type 2 diabetes.Impaired β cell function in Chinese newly diagnosed type 2 diabetes mellitus with hyperlipidemia.Comparison of effects of pitavastatin and atorvastatin on glucose metabolism in type 2 diabetic patients with hypercholesterolemia.Glucolipotoxicity of the pancreatic beta cell.Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based studyCarriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunctionInvestigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus.High density lipoproteins and type 2 diabetes: Emerging concepts in their relationship.Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.Bayes variable selection in semiparametric linear modelsExposure to high levels of glucose increases the expression levels of genes involved in cholesterol biosynthesis in rat isletsStatins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalinkBeta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport.The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitusHDL-replacement therapy: mechanism of action, types of agents and potential clinical indications.Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.Telmisartan improves insulin resistance of skeletal muscle through peroxisome proliferator-activated receptor-δ activation.Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: a cross-sectional studyMetabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects.Reconstituted high-density lipoprotein infusion modulates fatty acid metabolism in patients with type 2 diabetes mellitusHigh density lipoprotein: it's not just about lipid transport anymorePPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cellsSkeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein.Minireview: microRNA function in pancreatic β cells.Loss-of-function mutations in ABCA1 and enhanced β-cell secretory capacity in young adultsType 2 diabetes is associated with reduced ATP-binding cassette transporter A1 gene expression, protein and functionThe cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
P2860
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P2860
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
description
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im März 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/03/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/03/01)
@nl
наукова стаття, опублікована в березні 2007
@uk
مقالة علمية (نشرت في مارس 2007)
@ar
name
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@ast
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@en
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@nl
type
label
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@ast
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@en
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@nl
prefLabel
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@ast
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@en
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Beta-cell ABCA1 influences ins ...... to thiazolidinedione treatment
@en
P2093
Anne Q Reuwer
Brad J Marsh
Brian Rodrigues
C Bruce Verchere
James D Johnson
Jenelle M Timmins
John S Parks
Liam R Brunham
Terry D Pape
Zainisha Vasanji
P2860
P2888
P304
P3181
P356
10.1038/NM1546
P407
P577
2007-02-18T00:00:00Z