Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
about
Essential role of retinoblastoma protein in mammalian hair cell development and hearing.Retinoblastoma family genesCo-ordination of cell cycle and differentiation in the developing nervous systemCoordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expressionId family of helix-loop-helix proteins in cancerTropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liverMature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activityAbsence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusionId2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteinsEnucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetusDirect binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesisPhospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblastsThe retinoblastoma tumor-suppressor gene, the exception that proves the ruleExtrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma.Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid developmentThe role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblastsThe protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous systemRb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cellsDiverse roles of inhibitor of differentiation 2 in adaptive immunity.Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation.Formation of mammalian erythrocytes: chromatin condensation and enucleation.Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesisThe erythroblastic islandRb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells.Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiationHypoxic stress underlies defects in erythroblast islands in the Rb-null mouse.Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemiaIncreased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells.RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexesThe retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stressRb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesisPocket protein function in melanocyte homeostasis and neoplasia.Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.Erythroblastic islands: niches for erythropoiesis.Retinoblastoma function is essential for establishing lung epithelial quiescence after injury.Effects of hypoxia on heterotypic macrophage interactions.
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P2860
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
description
2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2004
@ast
scientific journal article
@en
vedecký článok (publikovaný 2004/12/23)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/12/23)
@nl
наукова стаття, опублікована в грудні 2004
@uk
مقالة علمية (نشرت في 23-12-2004)
@ar
name
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@ast
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@en
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@nl
type
label
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@ast
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@en
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@nl
prefLabel
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@ast
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@en
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@nl
P2093
P2860
P921
P356
P1433
P1476
Retinoblastoma promotes defini ...... Id2 in fetal liver macrophages
@en
P2093
Anna Lasorella
Antonio Iavarone
E. Richard Stanley
Emerson R. King
Xu-Ming Dai
P2860
P2888
P304
P356
10.1038/NATURE03068
P407
P577
2004-12-23T00:00:00Z
P6179
1003035459