The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
about
Transcription factor regulation of pancreatic organogenesis, differentiation and maturationGhrelin cells replace insulin-producing beta cells in two mouse models of pancreas developmentOsteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in miceThe transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cellsDevelopmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signalingThe zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cellsGenome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsIdentification of known and novel pancreas genes expressed downstream of Nkx2.2 during developmentGenetics of type 2 diabetes: insights into the pathogenesis and its clinical application.Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.The MafA transcription factor becomes essential to islet β-cells soon after birth.Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Molecular Ghrelin System in the Pancreatic Acinar Cells: The Role of the Polypeptide, Caerulein and Sensory Nerves.Identification of novel targets of CSL-dependent Notch signaling in hematopoiesisArx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineageEnhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method.Transcriptional regulation of α-cell differentiation.Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells.Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation MarkerNutrient excess stimulates β-cell neogenesis in zebrafish.Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells.An RNAi screen reveals intestinal regulators of branching morphogenesis, differentiation, and stem cell proliferation in planariansA switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cellsGenome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.Genetic modification of stem cells for transplantation.Endocrine pancreatic development: impact of obesity and diet.On the origin of the beta cell.Stem cells to pancreatic beta-cells: new sources for diabetes cell therapyProx1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.Pancreas cell fate.The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences.α-cell role in β-cell generation and regeneration.Pancreatic gene variants potentially associated with dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.β-cell differentiation status in type 2 diabetes.Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs.PAX4 gene variations predispose to ketosis-prone diabetes.
P2860
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P2860
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/02/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/01)
@nl
наукова стаття, опублікована в лютому 2004
@uk
مقالة علمية (نشرت في فبراير 2004)
@ar
name
The concerted activities of Pa ...... atic beta-cell differentiation
@ast
The concerted activities of Pa ...... atic beta-cell differentiation
@en
The concerted activities of Pa ...... atic beta-cell differentiation
@nl
type
label
The concerted activities of Pa ...... atic beta-cell differentiation
@ast
The concerted activities of Pa ...... atic beta-cell differentiation
@en
The concerted activities of Pa ...... atic beta-cell differentiation
@nl
prefLabel
The concerted activities of Pa ...... atic beta-cell differentiation
@ast
The concerted activities of Pa ...... atic beta-cell differentiation
@en
The concerted activities of Pa ...... atic beta-cell differentiation
@nl
P2093
P3181
P1476
The concerted activities of Pa ...... atic beta-cell differentiation
@en
P2093
Hasan Kizilocak
Junfeng Wang
Lynda Elghazi
Masahide Asano
Susan E. Parker
P304
P3181
P356
10.1016/J.YDBIO.2003.10.018
P407
P577
2004-02-01T00:00:00Z