Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
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Hematopoietic stem cell development, niches, and signaling pathwaysCytogenetic and molecular abnormalities in chronic myelomonocytic leukemiaThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerInflammation as a Driver of Clonal Evolution in Myeloproliferative NeoplasmJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsRare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traitsLNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitorsCo-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunctionAdaptor protein Lnk inhibits c-Fms-mediated macrophage functionGerm line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasmsMERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signalingMegakaryopoiesisThrombopoietin and hematopoietic stem cells.Lung as a Niche for Hematopoietic Progenitors.Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Lnk constrains myeloproliferative diseases in mice.The molecular regulation of Janus kinase (JAK) activationOcta-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms.Association Study of rs3184504 C>T Polymorphism in Patients With Coronary Artery Disease.Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche.ARAP3 functions in hematopoietic stem cellsIdentification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.ApoE is required for maintenance of the dentate gyrus neural progenitor poolNov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms.14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cellsConnexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cellsGetting blood from bone: an emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their nicheSignaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cellsAdaptor protein Lnk binds to and inhibits normal and leukemic FLT3.Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells.Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein.SH2B3 (LNK) mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F.A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosisType 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
P2860
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P2860
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/01)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية (نشرت في أغسطس 2008)
@ar
name
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@ast
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@en
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@nl
type
label
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@ast
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@en
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@nl
prefLabel
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@ast
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@en
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@nl
P2093
P2860
P3181
P356
P1476
Lnk controls mouse hematopoiet ...... direct interactions with JAK2
@en
P2093
Alexey Bersenev
Joanna Balcerek
P2860
P304
P3181
P356
10.1172/JCI35808
P407
P577
2008-08-01T00:00:00Z