Dax1 antagonizes Sry action in mammalian sex determination
about
Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determinationHuman RSPO1/R-spondin1 is expressed during early ovary development and augments β-catenin signalingOrphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNAUp-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutationsWnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergyIdentification of SOX3 as an XX male sex reversal gene in mice and humansDmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiationA novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadismMale sex determination: insights into molecular mechanismsDAX1: Increasing complexity in the roles of this novel nuclear receptorSF-1 a key player in the development and differentiation of steroidogenic tissuesNew clues to the puzzle of mammalian sex determinationZebrafish sex determination and differentiation: involvement of FTZ-F1 genesInteraction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenitaTestis development requires the repression of Wnt4 by Fgf signalingGenetic control of testis developmentPrimate DAX1, SRY, and SOX9: evolutionary stratification of sex-determination pathway.Dmrt1 expression is regulated by follicle-stimulating hormone and phorbol esters in postnatal Sertoli cellsSex determination in the chicken embryo.Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal.Transcriptional profiling of enriched populations of stem cells versus transient amplifying cells. A comparison of limbal and corneal epithelial basal cells.Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set.Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiationMammalian sex determination: joining pieces of the genetic puzzle.CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease.Induction of WNT inhibitory factor 1 expression by Müllerian inhibiting substance/antiMullerian hormone in the Müllerian duct mesenchyme is linked to Müllerian duct regression.New solutions to an ancient riddle: defining the differences between Adam and Eve.Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta.The road to maleness: from testis to Wolffian duct.Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis.The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification.Sex determination and the Y chromosome.Ovarian differentiation and gonadal failure.Autosomal XX sex reversal caused by duplication of SOX9.SRY interacts with and negatively regulates androgen receptor transcriptional activity.The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.Additional copies of CBX2 in the genomes of males of mammals lacking SRY, the Amami spiny rat (Tokudaia osimensis) and the Tokunoshima spiny rat (Tokudaia tokunoshimensis).X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein.Establishing sexual dimorphism: conservation amidst diversity?
P2860
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P2860
Dax1 antagonizes Sry action in mammalian sex determination
description
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1998
@ast
scientific journal article
@en
vedecký článok (publikovaný 1998/02/19)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/02/19)
@nl
наукова стаття, опублікована в лютому 1998
@uk
научни чланак (објављен 1998/02/19)
@sr
name
Dax1 antagonizes Sry action in mammalian sex determination
@ast
Dax1 antagonizes Sry action in mammalian sex determination
@en
Dax1 antagonizes Sry action in mammalian sex determination
@nl
type
label
Dax1 antagonizes Sry action in mammalian sex determination
@ast
Dax1 antagonizes Sry action in mammalian sex determination
@en
Dax1 antagonizes Sry action in mammalian sex determination
@nl
prefLabel
Dax1 antagonizes Sry action in mammalian sex determination
@ast
Dax1 antagonizes Sry action in mammalian sex determination
@en
Dax1 antagonizes Sry action in mammalian sex determination
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Dax1 antagonizes Sry action in mammalian sex determination
@en
P2093
G Camerino
P Burgoyne
R Lovell-Badge
P2860
P2888
P304
P3181
P356
10.1038/35799
P407
P50
P577
1998-02-01T00:00:00Z
P5875
P6179
1017899268