ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
about
Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNSBiochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndromeThe lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and functionDiscovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12)The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipaseActivity-based proteomic and metabolomic approaches for understanding metabolismMetabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions.In vivo metabolite profiling as a means to identify uncharacterized lipase function: recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family.Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout miceMetabolomic strategies to map functions of metabolic pathwaysChemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoidsExploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platformsMetabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways.Profile of Benjamin Cravatt.Phosphatidylserine in the brain: metabolism and function.Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.Type IV P-type ATPases distinguish mono- versus diacyl phosphatidylserine using a cytofacial exit gate in the membrane domain.Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects.More surprises lying ahead. The endocannabinoids keep us guessing.Endocannabinoids, related compounds and their metabolic routes.Monoglyceride lipase: Structure and inhibitors.An Introduction to the Endogenous Cannabinoid System.NMR-based Metabolomics Analysis of Liver from C57BL/6 Mouse Exposed to Ionizing Radiation.Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.The Arabidopsis ABHD11 Mutant Accumulates Polar Lipids in Leaves as a Consequence of Absent Acylhydrolase Activity.α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury.Chemical biologists rush to San Francisco for the ICBS.Monoacylglycerol signalling and ABHD6 in health and disease.Loss of Cannabinoid CB 1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.Lipoquality control by phospholipase A2 enzymes.A complex homozygous mutation in ABHD12 responsible for PHARC syndrome discovered with NGS and review of the literature.A Sensitive and Versatile Fluorescent Activity Assay for ABHD12.Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease.Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids
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P2860
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC
description
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2013
@ast
im Januar 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/01/22)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/01/22)
@nl
наукова стаття, опублікована в січні 2013
@uk
name
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@ast
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@en
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@nl
type
label
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@ast
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@en
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@nl
prefLabel
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@ast
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@en
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@nl
P2093
P2860
P921
P356
P1476
ABHD12 controls brain lysophos ...... eurodegenerative disease PHARC
@en
P2093
Benjamin F Cravatt
Jacqueline L Blankman
Jonathan Z Long
P2860
P304
P356
10.1073/PNAS.1217121110
P407
P577
2013-01-07T00:00:00Z