Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner
about
Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteinsEn1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1.Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout miceSlow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.Developmental origins of central norepinephrine neuron diversityAutism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum.Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behaviorEngrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus.Advances in behavioral genetics: mouse models of autism.Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursorsDevelopment of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains.Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.Chronic desipramine treatment rescues depression-related, social and cognitive deficits in Engrailed-2 knockout mice.Cell death as a regulator of cerebellar histogenesis and compartmentation.Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channels.Distinct transcriptomes define rostral and caudal serotonin neurons.Specific Connectivity and Unique Molecular Identity of MET Receptor Tyrosine Kinase Expressing Serotonergic Neurons in the Caudal Dorsal Raphe Nuclei.Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.Arborization pattern of engrailed-positive neural lineages reveal neuromere boundaries in the Drosophila brain neuropil.Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis.Redefining the serotonergic system by genetic lineageSerotonin neuron development: shaping molecular and structural identities.Clinical Phenotypes Associated to Engrailed 2 Gene Alterations in a Series of Neuropediatric Patients
P2860
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P2860
Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner
description
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artikull shkencor
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artículu científicu espublizáu en 2005
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im Januar 2005 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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wetenschappelijk artikel
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наукова стаття, опублікована в січні 2005
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مقالة علمية نشرت عام 2005 حول موضوع: دماغ
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name
Engrailed genes control develo ...... n a gene dose-dependent manner
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Engrailed genes control develo ...... n a gene dose-dependent manner
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Engrailed genes control develo ...... n a gene dose-dependent manner
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type
label
Engrailed genes control develo ...... n a gene dose-dependent manner
@ast
Engrailed genes control develo ...... n a gene dose-dependent manner
@en
Engrailed genes control develo ...... n a gene dose-dependent manner
@nl
prefLabel
Engrailed genes control develo ...... n a gene dose-dependent manner
@ast
Engrailed genes control develo ...... n a gene dose-dependent manner
@en
Engrailed genes control develo ...... n a gene dose-dependent manner
@nl
P2093
P921
P1476
Engrailed genes control develo ...... n a gene dose-dependent manner
@en
P2093
Christian Scholz
Dennis D. M. O'Leary
Horst H. Simon
P304
P356
10.1016/J.MCN.2004.08.016
P577
2005-01-01T00:00:00Z