Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells
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MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomesFunctional characterization of the human myosin-7a motor domainMyosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle.A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) miceMyosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complexFunctional auditory hair cells produced in the mammalian cochlea by in utero gene transfer.Focusing on the genetics of hearing: you ain't heard nothin' yet.Beyond generalized hair cells: molecular cues for hair cell typesSensing sound: molecules that orchestrate mechanotransduction by hair cellsMyosins in cell junctionsLGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti developmentThe structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteinsMouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cellsThe role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cellsTargeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutationFCHSD1 and FCHSD2 are expressed in hair cell stereocilia and cuticular plate and regulate actin polymerization in vitro.Biochemical and bioinformatic analysis of the myosin-XIX motor domain.Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.Genetics of auditory mechano-electrical transduction.Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochleaGene transfer in human vestibular epithelia and the prospects for inner ear gene therapy.Conditional and inducible gene recombineering in the mouse inner earThe balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing.Hearing loss: a common disorder caused by many rare alleles.Actin in hair cells and hearing loss.Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genesDiaphanous homolog 3 (Diap3) overexpression causes progressive hearing loss and inner hair cell defects in a transgenic mouse model of human deafness.The LINC complex is essential for hearing.Hair cell fate decisions in cochlear development and regenerationDimerized Drosophila myosin VIIa: a processive motor.A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereociliaThe micromachinery of mechanotransduction in hair cells.Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation
P2860
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P2860
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells
description
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im Februar 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/02/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/02/01)
@nl
наукова стаття, опублікована в лютому 1998
@uk
научни чланак (објављен 1998/02/01)
@sr
name
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@ast
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@en
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@nl
type
label
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@ast
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@en
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@nl
prefLabel
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@ast
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@en
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@nl
P2093
P3181
P1433
P1476
Shaker-1 mutations reveal role ...... unction of cochlear hair cells
@en
P2093
P304
P3181
P407
P577
1998-02-01T00:00:00Z