Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus
about
The construction of transgenic and gene knockout/knockin mouse models of human diseaseFor dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequentialEnhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populationsGeneration and characterization of a novel CYP2A13--transgenic mouse model.Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathwaysGenetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.Cytochrome P450 and xenobiotic receptor humanized mice.Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in Ouangolodougou (Northern Ivory Coast).Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicityMutaCYP: Classification of missense mutations in human cytochromes P450Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.CYP1A2--a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patientsGeneration and characterization of a CYP2A13/2B6/2F1-transgenic mouse modelGeneration of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse linePriorities and standards in pharmacogenetic research.Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis.Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor.Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessmentKnock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principleCYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell linesNovel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.Cytochrome P450 pharmacogenetics in African populations.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.Activity of cytochrome P450 1A2 in relation to hepatic iron accumulation in transfusion-dependent β-thalassaemia major patients.Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression.Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer.
P2860
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P2860
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus
description
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Februar 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/02/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/02/01)
@nl
наукова стаття, опублікована в лютому 2005
@uk
مقالة علمية (نشرت في فبراير 2005)
@ar
name
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@ast
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@en
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@nl
type
label
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@ast
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@en
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@nl
prefLabel
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@ast
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@en
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@nl
P2093
P2860
P3181
P356
P1433
P1476
Toward the evaluation of funct ...... the human CYP1A1_CYP1A2 locus
@en
P2093
Daniel W. Nebert
Howard G. Shertzer
Ranjan Deka
Timothy P. Dalton
Yutaka Tsuneoka
Zhengwen Jiang
P2860
P304
P3181
P356
10.1002/HUMU.20134
P577
2005-02-01T00:00:00Z