Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
about
The essential role of profilin in the assembly of actin for microspike formation.Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeletonThe Rac1 polybasic region is required for interaction with its effector PRK1Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylasesBiochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in plateletsPRK1 is targeted to endosomes by the small GTPase, RhoBp140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganizationIdentification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinaseIdentification of a novel guanine nucleotide exchange factor for the Rho GTPaseCentrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.The extended protein kinase C superfamilyRho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70Translocation of PKN from the cytosol to the nucleus induced by stressesThe PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organizationExpression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesRegulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathwayRho-stimulated contractility drives the formation of stress fibers and focal adhesionsEvidence for PDZ domains in bacteria, yeast, and plantsRho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail associationProteolytic activation of PKN by caspase-3 or related protease during apoptosisPhosphorylation of adducin by Rho-kinase plays a crucial role in cell motilityRoles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filamentsControl of T lymphocyte morphology by the GTPase Rho.The Rac1 hypervariable region in targeting and signaling: a tail of many storiesParallel coiled-coil association of the RhoA-binding domain in Rho-kinaseMolecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)Structure of the Bro1 Domain Protein BROX and Functional Analyses of the ALIX Bro1 Domain in HIV-1 BuddingCrystal structure of human RhoA in a dominantly active form complexed with a GTP analogueBni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae.Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast.Yeast Npi3/Bro1 is involved in ubiquitin-dependent control of permease trafficking.Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinaseRho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinaseMEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinaseThe RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organizationPKN regulates phospholipase D1 through direct interactionPulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolaseIdentification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP
P2860
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P2860
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
description
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1996
@ast
im Februar 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/02/02)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/02/02)
@nl
наукова стаття, опублікована в лютому 1996
@uk
name
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@ast
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@en
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@nl
type
label
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@ast
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@en
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@nl
prefLabel
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@ast
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@en
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@nl
P2093
P3181
P1433
P1476
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
@en
P2093
A. Kakizuka
G. Watanabe
K. Fujisawa
P. Madaule
S. Narumiya
T. Ishizaki
P304
P3181
P356
10.1126/SCIENCE.271.5249.645
P407
P577
1996-02-02T00:00:00Z