Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
about
Mutations in the human SIX3 gene in holoprosencephaly are loss of functionSonic hedgehog signaling in the development of the mouse hypothalamusUnique alterations of an ultraconserved non-coding element in the 3'UTR of ZIC2 in holoprosencephalyDefinition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palateCdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in miceSix3 regulates optic nerve development via multiple mechanisms.Eye development and retinogenesisWnt antagonism of Shh facilitates midbrain floor plate neurogenesisSix3 is required for ependymal cell maturationEvolution and development of interhemispheric connections in the vertebrate forebrainMechanisms that underlie co-variation of the brain and faceSimple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancerEthanol itself is a holoprosencephaly-inducing teratogen.The molecular genetics of holoprosencephaly.The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.Heterozygous mutations in SIX3 and SHH are associated with schizencephaly and further expand the clinical spectrum of holoprosencephaly.Genesis of teratogen-induced holoprosencephaly in mice.Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development.Molecular regulation of the developing commissural plateSerotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling.Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.Topography of Somatostatin Gene Expression Relative to Molecular Progenitor Domains during Ontogeny of the Mouse HypothalamusThe ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development.Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus.Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.The visual system of zebrafish and its use to model human ocular diseases.Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish.Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling.New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors.Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and functionProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesodermZebrafish Craniofacial Development: A Window into Early PatterningNODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos.Traces of embryogenesis are the same in monozygotic and dizygotic twins: not compatible with double ovulation.
P2860
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P2860
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/01)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية نشرت في أغسطس 2008 حول موضوع: دماغ
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name
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@ast
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@en
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@nl
type
label
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@ast
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@en
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@nl
prefLabel
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@ast
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@en
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@nl
P2093
P2860
P921
P3181
P1433
P1476
Haploinsufficiency of Six3 fai ...... n and causes holoprosencephaly
@en
P2093
Christina Speirs
Douglas J Epstein
Guillermo Oliver
Lilianna Solnica-Krezel
Oleg Lagutin
P2860
P304
P3181
P356
10.1016/J.DEVCEL.2008.07.003
P407
P50
P577
2008-08-01T00:00:00Z