Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter
about
Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expressionCD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanismCooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiationPearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor.The Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells.From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitmentCompound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progressionB lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.Diverse roles of inhibitor of differentiation 2 in adaptive immunity.Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site.Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activityTranscriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics.Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment.Transcriptional networks in developing and mature B cells.Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2ADifferential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice.Transcriptional repression of Gata3 is essential for early B cell commitment.Early B cell factor: Regulator of B lineage specification and commitmentThe 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes.Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineageOpposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5.Modeling the dynamics of transcriptional gene regulatory networks for animal development.Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytesTranscriptional and epigenetic regulation of B cell development.Acute lymphoblastic leukemia and developmental biology: a crucial interrelationshipBACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 functionMechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia.The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias).A novel pax5-binding regulatory element in the igκ locus.Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma.Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia.EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.
P2860
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P248
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P2860
Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter
description
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/12/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/12/01)
@nl
наукова стаття, опублікована в грудні 2002
@uk
مقالة علمية (نشرت في ديسمبر 2002)
@ar
name
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@ast
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@en
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@nl
type
label
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@ast
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@en
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@nl
prefLabel
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@ast
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@en
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@nl
P2093
P2860
P1476
Early B-cell factor, E2A, and ...... B cell-specific mb-1 promoter
@en
P2093
Carmen Yeamans
Daniel Fitzsimmons
Dawn R. Clark
Gongyi Zhang
James Hagman
Michelle Doyle
Mikael Sigvardsson
Peter Akerblad
Ronggui Li
Sven Bilke
P2860
P304
P356
10.1128/MCB.22.24.8539-8551.2002
P407
P577
2002-12-01T00:00:00Z