Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome - Wikidata - wikimedia - TriplyDB

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

http://www.wikidata.org/entity/Q28511291

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The dynamic cilium in human diseases Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome BBS mutations modify phenotypic expression of CEP290-related ciliopathies Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling The blind leading the obese: the molecular pathophysiology of a human obesity syndrome Recent advances in understanding leptin signaling and leptin resistance Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation 60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C Obesity genetics in mouse and human: back and forth, and back again Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway Leptin signaling and leptin resistance Primary cilia in the developing and mature brain Update on the genetics of bardet-biedl syndrome Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice Adult type 3 adenylyl cyclase-deficient mice are obese The nonmotile ciliopathies.Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?Sympathetic nervous system overactivity and its role in the development of cardiovascular disease Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver Ciliopathy is differentially distributed in the brain of a Bardet-Biedl syndrome mouse model Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.Brain tissue- and region-specific abnormalities on volumetric MRI scans in 21 patients with Bardet-Biedl syndrome (BBS)Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants.Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.Eating behaviors in obese children with pseudohypoparathyroidism type 1a: a cross-sectional study.Inactivation of Bardet-Biedl syndrome genes causes kidney defects.Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance.Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice.Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor.End stage renal disease, differential diagnosis, a rare genetic disorder: bardet-biedl syndrome: case report and review.Molecular basis of the obesity associated with Bardet-Biedl syndrome.BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane.Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice Hypothalamic Leptin Resistance: From BBB to BBSome.

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Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

http://www.wikidata.org/entity/Q28511291

description

2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2008

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im April 2008 veröffentlichter wissenschaftlicher Artikel

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scientific journal article

@en

vedecký článok (publikovaný 2008/04/01)

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vědecký článek publikovaný v roce 2008

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wetenschappelijk artikel (gepubliceerd op 2008/04/01)

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наукова стаття, опублікована у квітні 2008

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مقالة علمية (نشرت في أبريل 2008)

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Journal of Clinical Investigation

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Leptin resistance contributes ...... odels of Bardet-Biedl syndrome

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Christopher J. Berry

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Daniel R. Thedens

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Darryl Y. Nishimura

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Melissa A. Fath

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Robert Weiss

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Val C. Sheffield

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P2860

The Ciliopathies: An Emerging Class of Human Genetic Disorders

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

Identification of a novel Bardet-Biedl syndrome protein, BBS7, that shares structural features with BBS1 and BBS2.

Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)

Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome gene

Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11)

Clinical and genetic epidemiology of Bardet-Biedl syndrome in Newfoundland: a 22-year prospective, population-based, cohort study

Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome

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1458–1467

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scholarly article

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1700653

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10.1172/JCI32357

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4

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118

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2008-04-01T00:00:00Z

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18317593

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Bardet-Biedl syndrome 4 (human)

Bardet-Biedl syndrome 2 (human)

McKusick-Kaufman syndrome

arterial hypertension

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2262028

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