Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
about
The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cellsTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyAtaxia-telangiectasia: future prospectsChemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cellsRad4 mainly functions in Chk1-mediated DNA damage checkpoint pathway as a scaffold protein in the fission yeast Schizosaccharomyces pombeThe intersection between DNA damage response and cell death pathwaysUSP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damageChk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoAn ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cellsA PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATORWISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice.PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells.Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymesAlternative splicing of CHEK2 and codeletion with NF2 promote chromosomal instability in meningioma.EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Cell cycle- and DNA repair pathway-specific effects of apoptosis on tumor suppression.PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.Functions of the MRE11 complex in the development and maintenance of oocytesDefining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse ModelThe ATM signaling network in development and disease.Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stabilityDifferential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBSLoss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.The mre11 complex and the response to dysfunctional telomeres.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.The MRE11 complex: starting from the ends.The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.Inner nuclear membrane protein Lem2 facilitates Rad3-mediated checkpoint signaling under replication stress induced by nucleotide depletion in fission yeastReduced histone biosynthesis and chromatin changes arising from a damage signal at telomeresWorking together and apart: the twisted relationship of the Mre11 complex and Chk2 in apoptosis and tumor suppression.Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis PathwayBetanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy.Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
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P2860
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
description
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
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im Juli 2008 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2008/07/11)
@sk
vědecký článek publikovaný v roce 2008
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wetenschappelijk artikel (gepubliceerd op 2008/07/11)
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наукова стаття, опублікована в липні 2008
@uk
مقالة علمية (نشرت في 11-7-2008)
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name
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@ast
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@en
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@nl
type
label
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@ast
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@en
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@nl
prefLabel
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@ast
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@en
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@nl
P2093
P2860
P921
P1433
P1476
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage
@en
P2093
Carlos Cordon-Cardo
Suzana S Couto
Tulio Matos
P2860
P356
10.1016/J.MOLCEL.2008.04.028
P577
2008-07-01T00:00:00Z