Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
about
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitusCommon defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploringAdvancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient miceGenome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress responseLiving without Oxygen: Anoxia-Responsive Gene Expression and RegulationInterstitial Deletions at 6q14.1-q15 Associated with Obesity, Developmental Delay and a Distinct Clinical Phenotype.Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.Ncb5or deficiency increases fatty acid catabolism and oxidative stress.Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.Beta-Cell Injury in Ncb5or-null Mice is Exacerbated by Consumption of a High-Fat Diet.NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell deathPracticing biochemistry without a licenseLarge-scale molecular analysis of a 34 Mb interval on chromosome 6q: major refinement of the RP25 interval.The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity.Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat.NCB5OR Deficiency in the Cerebellum and Midbrain Leads to Dehydration and Alterations in Thirst Response, Fasted Feeding Behavior, and Voluntary Exercise in Mice.Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.The Human Obesity Gene Map: The 2004 Update
P2860
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P2860
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
description
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
@ast
im Juli 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/07/20)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/07/20)
@nl
наукова стаття, опублікована в липні 2004
@uk
name
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@ast
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@en
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@nl
type
label
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@ast
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@en
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@nl
prefLabel
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@ast
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@en
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@nl
P2093
P2860
P3181
P356
P1476
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
@en
P2093
Ayden Seguritan
Chen-Yu Zhang
Edward H Leiter
Evan D Rosen
H Franklin Bunn
Jianxin Xie
Kevin Larade
Michelle Chu
Roderick T Bronson
P2860
P304
10750-10755
P3181
P356
10.1073/PNAS.0404044101
P407
P50
P577
2004-07-09T00:00:00Z