Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
about
Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondriaMitochondrial genome changes and neurodegenerative diseasesNucleotide salvage deficiencies, DNA damage and neurodegenerationThymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in miceDeoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressZidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells.Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidationEarly-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice.Mitochondrial DNA mutations in disease and agingInhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function.Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondriaNucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.Mouse models of mitochondrial DNA defects and their relevance for human disease.Mouse models of oxidative phosphorylation dysfunction and diseaseTranscriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies.Development of pharmacological strategies for mitochondrial disorders.Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review.Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations.Infantile-onset disorders of mitochondrial replication and protein synthesis.Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes.Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.Mitochondrial dysfunction and ovarian aging.Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism.
P2860
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P2860
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/01)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/01)
@nl
наукова стаття, опублікована в серпні 2008
@uk
مقالة علمية (نشرت في أغسطس 2008)
@ar
name
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@ast
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@en
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@nl
type
label
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@ast
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@en
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@nl
prefLabel
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@ast
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@en
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@nl
P2093
P2860
P356
P1476
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
@en
P2093
Björn Rozell
Magnus Johansson
Mia Bjerke
Nicola Solaroli
Xiaoshan Zhou
P2860
P304
P356
10.1093/HMG/DDN133
P577
2008-04-22T00:00:00Z