Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense interventionA-to-I editing of coding and non-coding RNAs by ADARsNew Insights into the Biological Role of Mammalian ADARs; the RNA Editing ProteinsRegulation of Ion Channel and Transporter Function Through RNA EditingAdenosine-to-inosine RNA editing and human diseaseRNA-binding proteins in neurodegeneration: Seq and you shall receiveInhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.RNA Editing-Systemic Relevance and Clue to Disease Mechanisms?Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2α transcript to ensure normal development of nervous system and cranial neural crest cellsMotor neuron vulnerability and resistance in amyotrophic lateral sclerosis.Editing of neurotransmitter receptor and ion channel RNAs in the nervous systemCo-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neuronsUnravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.Novel RNA modifications in the nervous system: form and functionThe emerging role of RNA editing in plasticity.The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brainIonotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder.Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons.ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticityActivity-regulated RNA editing in select neuronal subfields in hippocampus.Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous systemA-to-I RNA editing: effects on proteins key to neural excitabilityOpen Randomized Clinical Trial on JWSJZ Decoction for the Treatment of ALS Patients.ADARs: allies or enemies? The importance of A-to-I RNA editing in human disease: from cancer to HIV-1.Activity regulation of adenosine deaminases acting on RNA (ADARs).Genetic and epigenetic studies of amyotrophic lateral sclerosis.The RNA editing enzymes ADARs: mechanism of action and human disease.Inhibitory dysfunction in amyotrophic lateral sclerosis: future therapeutic opportunities.ADAR RNA editing below the backbone.Modeling simple repeat expansion diseases with iPSC technology.The Good and the Bad of Glutamate Receptor RNA Editing.When Does ALS Start? ADAR2-GluA2 Hypothesis for the Etiology of Sporadic ALS.Altered Intracellular Milieu of ADAR2-Deficient Motor Neurons in Amyotrophic Lateral SclerosisADAR RNA editing in human disease; more to it than meets the I.Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons.Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALSActivity-dependent A-to-I RNA editing in rat cortical neurons.Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.
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P2860
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/09/08)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/08)
@nl
наукова стаття, опублікована у вересні 2010
@uk
مقالة علمية (نشرت في 8-9-2010)
@ar
name
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@ast
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@en
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@nl
type
label
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@ast
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@en
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@nl
prefLabel
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@ast
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@en
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@nl
P2093
P921
P3181
P1476
Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2
@en
P2093
Hidemi Misawa
Miyoko Higuchi
Peter H Seeburg
Ryosuke Takahashi
Shoji Tsuji
Takenari Yamashita
Takeshi Suzuki
Takuto Hideyama
P304
11917-11925
P3181
P356
10.1523/JNEUROSCI.2021-10.2010
P407
P577
2010-09-01T00:00:00Z