The nuclear membrane organization of leukotriene synthesis
about
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cellsEicosanoid storm in infection and inflammationRoles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesisLocation, location, location: compartmentalization of early events in leukotriene biosynthesis.Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins.Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors.Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.Dual anti-inflammatory and selective inhibition mechanism of leukotriene A4 hydrolase/aminopeptidase: insights from comparative molecular dynamics and binding free energy analyses.Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis.Leukotrienes and airway inflammationCytosolic phospholipase A₂: physiological function and role in disease.Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanismThe nuclear membrane leukotriene synthetic complex is a signal integrator and transducer.Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils.Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formationJoint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritisRole of cells and mediators in exercise-induced bronchoconstriction.Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation.CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functionsDual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.An update on the role of leukotrienes in asthma.Tetraspanins in mast cellsAndrogen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents.Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome.Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor.ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.Hybrid Receptor-Bound/MM-GBSA-Per-residue Energy-Based Pharmacophore Modelling: Enhanced Approach for Identification of Selective LTA4H Inhibitors as Potential Anti-inflammatory Drugs.Leukotriene inflammatory mediators meet their match.Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.
P2860
03d806f088ccb6750c42ed0b167a09f4808595951fc69dce27a02372363c5e03079f5df60c1823f739db4f19c7abde49ae3dcd095f916b4e05dbd70b5c65a843edaa82b8f5d4407556ef272573343df7625e1093bac27c622df292100595b68cb740ce5b666f39eb32582a12b27210b1902933e68587ace2b7f9afb62871baa6e8388f9bb6a65b1fdc5e95c8d07c73eb41baaf406aa17f0dd4d826ae37890fd6
P248
Q24321415-FE073614-BD62-4AEB-A6A0-7C3A07FFA93CQ26851985-65BFB831-BE38-4CD1-A314-927F1B11E5F8Q34025563-07CBE79C-03D3-49CD-AB1E-58BE490AEA6DQ34055661-1F9A1161-9B1E-48DC-8751-EA2D70450DFCQ34113615-F76C59EC-3748-4741-A4A5-726FA556B149Q34308008-8060D207-334A-4312-B406-0BA0171FAF6AQ34438801-C2DA01C6-0BD1-44A5-8975-4425FEE766C1Q34501278-A42917F5-D080-4122-BC6A-50366804A22BQ34769347-473944FE-0BA7-4C6B-9969-77F072A33594Q35106124-096CB080-9E80-43C2-ACA5-CB5F8625479AQ35886245-2801E03D-804A-417A-9111-36ECE56AA3ACQ36177942-A1BD0D4B-8DBE-4776-99EF-A6D740821B33Q36394571-F8DC6938-707D-4C18-B7FF-D681CE710206Q36414954-898859B8-7C1E-40C0-85CB-AAE2669C5F8CQ36620215-88C1F714-D625-466F-A25A-ABF04C396FD2Q36812054-922129B3-48B4-4FB9-A808-1F5228095FEEQ36948733-EDFB3323-BC16-48B6-B582-BCC118E72267Q37149221-C25A22C3-5DE2-478F-8E02-DEFA98223B57Q37208628-2F9D3898-C6CA-489F-92F7-2CF04C594AD3Q37270602-66F19519-EDC3-473E-A6B4-3C215C20114BQ37344116-68C5BB4B-A9F1-4712-AAF1-21057F8C47FFQ37633331-84E0E5F3-A7F2-4F70-8A54-0EB310F3B602Q38025396-7947281C-D284-4DD0-AD7A-BFFBCE7EFC8DQ38665189-99ABB0D1-3DEF-4A08-BEDA-7D54AF33587CQ39049264-6FA42E97-F508-4812-A4DD-EAAE9A59366FQ40205251-86AA9740-EAA5-49E7-897C-384EEDF26432Q41518288-637352CC-2776-44A4-9279-FE25A9C10097Q41774015-2B0C31D8-8756-4F66-9298-977A3D2ADBE3Q42098828-AFD0E1C4-E499-41C2-A35A-3003BF811FE0Q46213251-477BFBBE-B90A-461A-880C-A8FFFE7D94D6Q48706704-75970409-19DF-41E0-91B6-0F38B2774BFEQ49679435-EA47C066-757C-48CE-A88F-CB94E6B7B070
P2860
The nuclear membrane organization of leukotriene synthesis
description
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2008
@ast
im Dezember 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/12/23)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/12/23)
@nl
наукова стаття, опублікована в грудні 2008
@uk
name
The nuclear membrane organization of leukotriene synthesis
@ast
The nuclear membrane organization of leukotriene synthesis
@en
The nuclear membrane organization of leukotriene synthesis
@nl
type
label
The nuclear membrane organization of leukotriene synthesis
@ast
The nuclear membrane organization of leukotriene synthesis
@en
The nuclear membrane organization of leukotriene synthesis
@nl
prefLabel
The nuclear membrane organization of leukotriene synthesis
@ast
The nuclear membrane organization of leukotriene synthesis
@en
The nuclear membrane organization of leukotriene synthesis
@nl
P2093
P2860
P921
P356
P1476
The nuclear membrane organization of leukotriene synthesis
@en
P2093
Angela M. Bair
Asim K. Mandal
Boris Nikolic
Brian Bacskai
David M. Lee
Douglas Miller
Douglas Wisniewski
Jilly F. Evans
John Menke
P2860
P304
20434–20439
P356
10.1073/PNAS.0808211106
P407
P577
2008-12-23T00:00:00Z