Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents
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Insights into Newer Antimicrobial Agents Against Gram-negative BacteriaUse of microdosing and accelerator mass spectrometry to evaluate the pharmacokinetic linearity of a novel tricyclic GyrB/ParE inhibitor in ratsA novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics.Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Protective effect of Qnr on agents other than quinolones that target DNA gyrase.Management of Intra-abdominal Infections due to Carbapenemase-Producing Organisms.Mutant Alleles of lptD Increase the Permeability of Pseudomonas aeruginosa and Define Determinants of Intrinsic Resistance to Antibiotics.Targeting bacterial topoisomerases: how to counter mechanisms of resistance.Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an InhibitorEscherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics.In vitro and in vivo activities of DS-2969b, a novel GyrB inhibitor, and its water-soluble prodrug, DS11960558, against methicillin-resistant Staphylococcus aureus.Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit.NMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitorNew N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
P2860
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P2860
Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents
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2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@ast
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
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Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
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type
label
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@ast
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@en
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@nl
prefLabel
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@ast
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@en
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@nl
P2093
P2860
P1433
P1476
Tricyclic GyrB/ParE (TriBE) in ...... targeting antibacterial agents
@en
P2093
Amanda Castellano
Bryan P Kwan
Chris M Pillar
Daniel C Bensen
Dean L Shinabarger
Doug Phillipson
Felice C Lightstone
Grayson Hough
Jeff B Locke
P2860
P304
P356
10.1371/JOURNAL.PONE.0084409
P407
P50
P577
2013-01-01T00:00:00Z