Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency
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Current Status: Site-Specific Antibody Drug ConjugatesSpontaneous Isopeptide Bond Formation as a Powerful Tool for Engineering Site-Specific Antibody-Drug Conjugates.Site-specific protein labeling via sortase-mediated transpeptidation.Sortase A-Generated Highly Potent Anti-CD20-MMAE Conjugates for Efficient Elimination of B-Lineage Lymphomas.Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts.Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiencyEfficient expression of sortase A from Staphylococcus aureus in Escherichia coli and its enzymatic characterizations.Stable and Potent Selenomab-Drug Conjugates.Affinity Maturation of a Cyclic Peptide Handle for Therapeutic Antibodies Using Deep Mutational Scanning.Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma.Antibody-drug conjugates: recent advances in conjugation and linker chemistries.Site-selective orientated immobilization of antibodies and conjugates for immunodiagnostics development.Strategies and challenges for the next generation of antibody-drug conjugates.Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities.Current progress in innovative engineered antibodies.One-step purification and immobilization of extracellularly expressed sortase A by magnetic particles to develop a robust and recyclable biocatalystHarnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugatesImproving theranostics in pancreatic cancer.A Versatile Chemo-Enzymatic Conjugation Approach Yields Homogeneous and Highly Potent Antibody-Drug Conjugates.Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9.Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27-28, 2017, Tours, France.Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.Site-Specific Antibody Conjugation for ADC and Beyond.Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice.RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor modelsNovel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells
P2860
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P2860
Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency
description
2015 nî lūn-bûn
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2015 թուականին հրատարակուած գիտական յօդուած
@hyw
2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@ast
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@en
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@nl
type
label
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@ast
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@en
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@nl
prefLabel
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@ast
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@en
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@nl
P2093
P2860
P3181
P1433
P1476
Sortase Enzyme-Mediated Genera ...... h In Vitro and In Vivo Potency
@en
P2093
Anna S Merkel
Roger R Beerli
Tamara Hell
Ulf Grawunder
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0131177
P407
P577
2015-01-01T00:00:00Z