Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
about
The PI3K-PDK1 connection: more than just a road to PKBSevere diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaPhylogenetic analysis of eIF4E-family membersInhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CHierarchical phosphorylation of the translation inhibitor 4E-BP1Integrating signals from T-cell receptor and serum by T cells enhance translation of tumour necrosis factor-alphaInsulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase AktA role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscleTarget of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionAnti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. Possible treatment options for TSC and LAM.Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling.A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes.4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.Akt/protein kinase B promotes organ growth in transgenic mice.Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor.Hypoxia-inducible factor-1 in tumour angiogenesis.Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1alpha and mediates its destabilization in a VHL-independent manner.The conserved phosphoinositide 3-kinase pathway determines heart size in mice.Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism.Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH₂-terminal (sites 2 + 2a) phosphorylation4E-BP1 regulates the differentiation of white adipose tissue.Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liverHER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells.HER2 signaling enhances 5'UTR-mediated translation of c-Myc mRNA.Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis.Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR.PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways.Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.TNF-alpha induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes.Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin.The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells.Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators.Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species.Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.Regulation of arterial blood pressure by Akt1-dependent vascular relaxation.
P2860
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P2860
Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
description
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Juli 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/07/16)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/07/16)
@nl
наукова стаття, опублікована в липні 1999
@uk
name
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@ast
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@en
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@nl
type
label
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@ast
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@en
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@nl
prefLabel
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@ast
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@en
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@nl
P2093
P2860
P356
P1476
Requirement for Akt (protein k ...... phorylation of 4E-BP1 (PHAS-1)
@en
P2093
A. C. Gingras
N. Sonenberg
T. Kitamura
P2860
P304
20611–20618
P356
10.1074/JBC.274.29.20611
P407
P577
1999-07-16T00:00:00Z