Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
about
Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variabilityBile acid transportersPediatric Statin Administration: Navigating a Frontier with Limited DataIntegration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function.Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participantsBile formation and secretion.Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice.Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp.Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.Hepatobiliary transport in health and diseaseClinical implications of pharmacogenomics of statin treatment.What do drug transporters really do?Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans.Prediction of drug-induced intrahepatic cholestasis: in vitro screening and QSAR analysis of drugs inhibiting the human bile salt export pump.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Physiology of bile secretion.Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).Transplacental transfer and distribution of pravastatin.Evaluation of the endothelin receptor antagonists ambrisentan, bosentan, macitentan, and sitaxsentan as hepatobiliary transporter inhibitors and substrates in sandwich-cultured human hepatocytes.The role of transporters in the pharmacokinetics of orally administered drugs.Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.Role of the bile salt export pump, BSEP, in acquired forms of cholestasis.Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis.Pharmacogenetics of drug transporters in the enterohepatic circulation.Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.Lipid-lowing pharmacogenomics in Chinese patients.Phase 0 and phase III transport in various organs: combined concept of phases in xenobiotic transport and metabolism.Effect of drug transporter pharmacogenetics on cholestasis.Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.Effect of Liver Disease on Hepatic Transporter Expression and Function.Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP.Effect of nine diets on xenobiotic transporters in livers of mice.
P2860
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P2860
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
description
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im August 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/08/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/08/01)
@nl
наукова стаття, опублікована в серпні 2005
@uk
مقالة علمية (نشرت في أغسطس 2005)
@ar
name
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@ast
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@en
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@nl
type
label
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@ast
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@en
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@nl
prefLabel
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@ast
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@en
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@nl
P2093
P356
P1476
Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin
@en
P2093
Hiroyuki Kusuhara
Kazuya Maeda
Masaru Hirano
Yuichi Sugiyama
P304
P356
10.1124/JPET.105.084830
P407
P577
2005-05-18T00:00:00Z