Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus
about
Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and SensitivityPhosphatidylinositol 3-kinase is an upstream regulator of the phosphodiesterase 3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus.Central insulin and leptin-mediated autonomic control of glucose homeostasis.The PI3K signaling pathway mediates the biological effects of leptin.Hypothalamic glycogen synthase kinase 3β has a central role in the regulation of food intake and glucose metabolism.Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity.Phosphoinositide 3-Kinase Is Involved in Mediating the Anti-inflammation Effects of Vasopressin.Acute inhibition of central c-Jun N-terminal kinase restores hypothalamic insulin signalling and alleviates glucose intolerance in diabetic mice.The dietary flavonoids naringenin and quercetin acutely impair glucose metabolism in rodents possibly via inhibition of hypothalamic insulin signalling.Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivoExtended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength.Phosphodiesterase-3B-cAMP pathway of leptin signalling in the hypothalamus is impaired during the development of diet-induced obesity in FVB/N mice.SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.Central Effects of Leptin on Glucose Homeostasis are Modified during Pregnancy in the Rat.Central Regulation of Glucose Homeostasis.
P2860
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P2860
Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus
description
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Juni 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/06/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/06/01)
@nl
наукова стаття, опублікована в червні 2010
@uk
مقالة علمية (نشرت في يونيو 2010)
@ar
name
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@ast
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@en
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@nl
type
label
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@ast
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@en
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@nl
prefLabel
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@ast
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@en
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@nl
P2093
P1476
Both p110alpha and p110beta is ...... signalling in the hypothalamus
@en
P2093
C. Chaussade
G. M. Anderson
P. R. Shepherd
R. A. Augustine
P304
P356
10.1111/J.1365-2826.2010.01975.X
P50
P577
2010-06-01T00:00:00Z