Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation
about
Modeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologuePhosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMPThe substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter.Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.Cytoplasmic permeation pathway of neurotransmitter transporters.Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transportersLocation of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.Unifying concept of serotonin transporter-associated currentsInvolvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.Identification of a chloride ion binding site in Na+/Cl -dependent transporters.Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.Mechanism for alternating access in neurotransmitter transporters.Control of serotonin transporter phosphorylation by conformational state.Conformational flexibility of helix VI is essential for substrate permeation of the human apical sodium-dependent bile acid transporterFunctional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site.Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization.The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin.Cholesterol binding to a conserved site modulates conformation, pharmacology and transport kinetics of the human serotonin transporter.The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.The cytoplasmic substrate permeation pathway of serotonin transporter.
P2860
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P2860
Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation
description
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im September 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/09/02)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/09/02)
@nl
наукова стаття, опублікована у вересні 2005
@uk
name
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@ast
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@en
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@nl
type
label
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@ast
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@en
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@nl
prefLabel
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@ast
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@en
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@nl
P2860
P356
P1476
Cysteine-scanning mutagenesis ...... an alpha-helical conformation
@en
P2093
Gary Rudnick
Yuan-Wei Zhang
P2860
P304
30807–30813
P356
10.1074/JBC.M504087200
P407
P577
2005-09-02T00:00:00Z