Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986
about
Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksFine-tuning multiprotein complexes using small moleculesRegulators of G-protein signaling in the heart and their potential as therapeutic targets.A high throughput screen for RGS proteins using steady state monitoring of free phosphate formationReversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteinsRegulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteinsReversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heartRegulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transductionRGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectivesNeurabin: a key factor in the specific neuroprotection mediated by Adenosine.RGS17: an emerging therapeutic target for lung and prostate cancers.Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers.Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.The Gαi-GIV binding interface is a druggable protein-protein interactionSmall Molecule Inhibitors of Regulator of G Protein Signalling (RGS) ProteinsNeurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.RGS Proteins in Heart: Brakes on the Vagus.Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling.Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family.A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.
P2860
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P2860
Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986
description
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im September 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2010/09/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/09/01)
@nl
наукова стаття, опублікована у вересні 2010
@uk
مقالة علمية (نشرت في سبتمبر 2010)
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name
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@ast
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@en
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@nl
type
label
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@ast
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@en
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@nl
prefLabel
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@ast
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@en
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@nl
P2093
P2860
P356
P1476
Allosteric inhibition of the r ...... rotein interaction by CCG-4986
@en
P2093
C Aaron Monroy
David L Roman
Levi L Blazer
P2860
P304
P356
10.1124/MOL.109.063388
P50
P577
2010-06-07T00:00:00Z