Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction
about
Integrating the biophysical and molecular mechanisms of auditory hair cell mechanotransductionIntestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulationIs TMC1 the Hair Cell Mechanotransducer Channel?Sensing sound: molecules that orchestrate mechanotransduction by hair cellsThe myosin superfamily at a glance.Structures of usher syndrome 1 proteins and their complexesA Biophysical Model for the Staircase Geometry of StereociliaCyclic nucleotide-gated channel α-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransductionHCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2TMHS is an integral component of the mechanotransduction machinery of cochlear hair cellsThe E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammalsThe murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities.Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein.The physiology of mechanoelectrical transduction channels in hearing.Genetics of auditory mechano-electrical transduction.Actin in hair cells and hearing loss.Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genesLocalization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice.Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications.Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia.Stable single α-helices are constant force springs in proteinsUsing injectoporation to deliver genes to mechanosensory hair cellsComplexes of Usher proteins preassemble at the endoplasmic reticulum and are required for trafficking and ER homeostasis.Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer.Unconventional mechanics of lipid membranes: a potential role for mechanotransduction of hair cell stereocilia.Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundlesMechanisms of otoconia and otolith developmentCLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.Structure and Regulation of the Movement of Human Myosin VIIA.TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell StereociliaUSH1G with unique retinal findings caused by a novel truncating mutation identified by genome-wide linkage analysis.Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.Localization of PDZD7 to the stereocilia ankle-link associates this scaffolding protein with the Usher syndrome protein networkUSH1K, a novel locus for type I Usher syndrome, maps to chromosome 10p11.21-q21.1.Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform.
P2860
Q22337239-1E0063FE-48F1-40CF-8A9D-262A0D814E01Q24294411-981BF71E-2C65-45B2-A0E2-BB524EED25A3Q24310646-3A27EC59-AE67-400E-8D71-A2B904CA0A54Q24315139-06F1E9C7-E480-4AB4-81F7-988D565BFA2FQ26740537-2D4B41D0-EC02-4D28-8D05-AB4821982BFBQ26866077-44DA07B4-2747-490B-8B6E-CBB359312FEAQ27011868-ACF84917-2239-4342-8359-5817D043FCDEQ27023615-450985D8-9A2C-4A7B-AB05-57B78DE752B0Q28546772-C73AA363-FF7C-4333-947E-7A8746AAAD26Q28570825-2F6E3B12-AE47-40A6-9CE6-C77C0C1A078BQ28584355-B9B53913-2464-4520-A07E-8D5122FF89D4Q28593852-B59A9EC6-C282-445F-8970-95AE62AD4FD2Q28830903-0E2A4321-B873-4777-8400-47BD6804AA20Q30354602-AA99A539-89ED-4F9A-883D-01083CD270D9Q30357625-4340D377-E33B-458B-B183-F35E97EF9634Q30389509-053F3F4A-C550-40BD-BA37-FDBC908A693FQ30393797-CD1E0F28-C665-4C6C-8378-F7A3D7FE8BD5Q30408022-A57F224F-B3C8-4839-87B9-33C7B8333260Q30421422-E94ECE4C-D3F2-4107-A0B7-7CDF28BA9959Q30454015-EB2811B8-6331-4412-96E2-641628F824E5Q30454026-00603367-B8C3-493E-AD46-47AB5C0DF8ACQ30455456-7A2AF297-ACDC-4DFB-BE63-6300EF67FD44Q30465350-1F6AE411-746C-4A30-AF13-77DE886F3100Q30525334-29E7A7A6-B736-4228-96D3-BACBF07B9C57Q30588808-07E288F4-322D-4B5E-B499-48ADB8A9099AQ30601270-3A2B34AD-7FEB-40CA-A485-5D9C04811DF4Q33556001-DB9E6E27-6A31-4342-88A1-CE23E7978714Q34517569-2CFC71A6-0027-47B2-B3D8-41FC15A0D24AQ35050601-DEF12647-7BE0-4047-804F-B3A5FC8EE24AQ35534680-78235D8F-3060-4889-8799-EF767B300465Q35788255-418F4EE6-FB1D-4F05-BE85-CF7CC2F220F8Q35795161-BD458141-97DF-455B-92B7-5131B3D15CD5Q35837241-4A349CFC-9E4D-4BCB-8EC9-4268A846E52EQ36057785-FBEA7D8D-7308-4F74-A806-AE2BF3F9F7F8Q36146000-2AD827C2-8F7B-4FEC-8D85-2EBD02C488D2Q36422283-E459FFAD-6E0D-4C9D-885F-B1E6F844016EQ36456242-E38CCC2D-087A-48A5-9505-00BB94029A50Q36680172-45EA2EBB-7BE3-4389-BC71-2A4E51204EC6Q36727696-00376663-F5B5-4A9F-BA58-D88AEC7F7455Q36803634-AD776791-AB8E-4210-B4D9-2C7757640DF7
P2860
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction
description
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2011
@ast
im Juli 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/07/12)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/07/12)
@nl
наукова стаття, опублікована в липні 2011
@uk
name
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@ast
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@en
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@nl
type
label
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@ast
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@en
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@nl
prefLabel
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@ast
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@en
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@nl
P2860
P3181
P356
P1476
Myosin VIIa and sans localizat ...... roteins in mechanotransduction
@en
P2093
Bechara Kachar
P2860
P304
11476-11481
P3181
P356
10.1073/PNAS.1104161108
P407
P50
P577
2011-06-27T00:00:00Z