The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2
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Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual SubtypesStructure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptideVisualization of arrestin recruitment by a G-protein-coupled receptorBeta-arrestins: multifunctional cellular mediatorsImpaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptorBiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics.The power of mass spectrometry in structural characterization of GPCR signaling.A Comprehensive View of the β-Arrestinome.A protein tyrosine phosphatase inhibitor, pervanadate, inhibits angiotensin II-Induced beta-arrestin cleavage.Functional competence of a partially engaged GPCR-β-arrestin complexCore engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation.G protein-coupled receptors--recent advancesβ-Arrestin-mediated receptor trafficking and signal transductionEmerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingSpecificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function.Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptorsDistinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.The β-Arrestins: Multifunctional Regulators of G Protein-coupled ReceptorsArrestin binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences.Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2Down-regulation of β-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinomaRole of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.Custom-designed proteins as novel therapeutic tools? The case of arrestins.β-Arrestins: multifunctional signaling adaptors in type 2 diabetes.Synthetic biology with surgical precision: targeted reengineering of signaling proteins.β-arrestins and G protein-coupled receptor trafficking.Biased agonism: An emerging paradigm in GPCR drug discovery.Arrestins: Critical Players in Trafficking of Many GPCRs.Depletion of β-arrestin2 in hepatic stellate cells reduces cell proliferation via ERK pathway.A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.The C-terminus region of β-arrestin1 modulates VE-cadherin expression and endothelial cell permeability.Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors.Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.The role and mechanism of β‑arrestins in cancer invasion and metastasis (Review).A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.Structure and dynamics of GPCR signaling complexes.Elevated β-arrestin1 expression correlated with risk stratification in acute lymphoblastic leukemia.Catalytic activation of β-arrestin by GPCRs.
P2860
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P2860
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2
description
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2007
@ast
im Juli 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/07/20)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/07/20)
@nl
наукова стаття, опублікована в липні 2007
@uk
name
The active conformation of bet ...... ates of beta-arrestins1 and -2
@ast
The active conformation of bet ...... ates of beta-arrestins1 and -2
@en
The active conformation of bet ...... ates of beta-arrestins1 and -2
@nl
type
label
The active conformation of bet ...... ates of beta-arrestins1 and -2
@ast
The active conformation of bet ...... ates of beta-arrestins1 and -2
@en
The active conformation of bet ...... ates of beta-arrestins1 and -2
@nl
prefLabel
The active conformation of bet ...... ates of beta-arrestins1 and -2
@ast
The active conformation of bet ...... ates of beta-arrestins1 and -2
@en
The active conformation of bet ...... ates of beta-arrestins1 and -2
@nl
P2093
P3181
P356
P1476
The active conformation of bet ...... ates of beta-arrestins1 and -2
@en
P2093
Kelly N. Nobles
Kunhong Xiao
Robert J. Lefkowitz
Terrence G. Oas
Ziqiang Guan
P304
21370–21381
P3181
P356
10.1074/JBC.M611483200
P407
P577
2007-07-20T00:00:00Z