Structural basis for the inhibitory role of tomosyn in exocytosis
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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegansELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapsesDistinct initial SNARE configurations underlying the diversity of exocytosisHelical extension of the neuronal SNARE complex into the membraneComplexin has opposite effects on two modes of synaptic vesicle fusionPositional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretionStructural and functional analysis of tomosyn identifies domains important in exocytotic regulationSNAREs--engines for membrane fusionTomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapsesSyntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungiIn vivo analysis of conserved C. elegans tomosyn domains.Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationDifferential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1.Factors regulating the abundance and localization of synaptobrevin in the plasma membrane.Tomosyn-dependent regulation of synaptic transmission is required for a late phase of associative odor memoryGPCR mediated regulation of synaptic transmission.Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure.Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensitive factor attachment protein-25.Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release.Reciprocal intramolecular interactions of tomosyn control its inhibitory activity on SNARE complex formation.Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming.Insulin granule biogenesis, trafficking and exocytosis.Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.Receptor-mediated regulation of tomosyn-syntaxin 1A interactions in bovine adrenal chromaffin cells.A coiled coil trigger site is essential for rapid binding of synaptobrevin to the SNARE acceptor complex.SNAREing the basis of multicellularity: consequences of protein family expansion during evolution.The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.v-SNARE function in chromaffin cells.Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.Arachidonic acid potentiates exocytosis and allows neuronal SNARE complex to interact with Munc18a.Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.Budding insights on cell polarity
P2860
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P2860
Structural basis for the inhibitory role of tomosyn in exocytosis
description
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im November 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/11/05)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/11/05)
@nl
наукова стаття, опублікована в листопаді 2004
@uk
name
Structural basis for the inhibitory role of tomosyn in exocytosis
@ast
Structural basis for the inhibitory role of tomosyn in exocytosis
@en
Structural basis for the inhibitory role of tomosyn in exocytosis
@nl
type
label
Structural basis for the inhibitory role of tomosyn in exocytosis
@ast
Structural basis for the inhibitory role of tomosyn in exocytosis
@en
Structural basis for the inhibitory role of tomosyn in exocytosis
@nl
prefLabel
Structural basis for the inhibitory role of tomosyn in exocytosis
@ast
Structural basis for the inhibitory role of tomosyn in exocytosis
@en
Structural basis for the inhibitory role of tomosyn in exocytosis
@nl
P2093
P2860
P3181
P356
P1476
Structural basis for the inhibitory role of tomosyn in exocytosis
@en
P2093
Adelia Razeto
Ajaybabu V Pobbati
Matthias Böddener
Stefan Becker
P2860
P304
47192-47200
P3181
P356
10.1074/JBC.M408767200
P407
P577
2004-08-16T00:00:00Z