Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsTranslational implications of the β-cell epigenome in diabetes mellitusSpecific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survivalDeletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosisA Common Susceptibility Gene for Type 2 Diabetes Is Associated with Drug Response to a DPP-4 Inhibitor: Pharmacogenomic Cohort in Okinawa JapanReplication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesA genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsA variant in CDKAL1 influences insulin response and risk of type 2 diabetesUncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Invited commentary: Gene X lifestyle interactions and complex disease traits--inferring cause and effect from observational data, sine qua non.Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus.The emerging genetic architecture of type 2 diabetesCyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.Cdk5 inhibitory peptide (CIP) inhibits Cdk5/p25 activity induced by high glucose in pancreatic beta cells and recovers insulin secretion from p25 damage.Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.Frequent loss of genome gap region in 4p16.3 subtelomere in early-onset type 2 diabetes mellitus.Novel genomic signals of recent selection in an Ethiopian population.PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress.DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients.Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-RasA new era for Type 2 diabetes geneticsCdk5r1 Overexpression Induces Primary β-Cell Proliferation.Association of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects.Gene Polymorphism Association with Type 2 Diabetes and Related Gene-Gene and Gene-Environment Interactions in a Uyghur Population.The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population.Genetics of type 2 diabetes mellitus and obesity--a review.CDKAL1 gene rs7756992 A/G polymorphism and type 2 diabetes mellitus: a meta-analysis of 62,567 subjects.Risk loci for type 2 diabetes - quo vadis?A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibilityMOPAT: a graph-based method to predict recurrent cis-regulatory modules from known motifs.Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus.GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.Association of polymorphic markers of genes FTO, KCNJ11, CDKAL1, SLC30A8, and CDKN2B with type 2 diabetes mellitus in the Russian population.Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.Replication study of novel risk variants in six genes with type 2 diabetes and related quantitative traits in the Han Chinese lean individuals.The carriage of risk variants of CDKAL1 impairs beta-cell function in both diabetic and non-diabetic patients and reduces response to non-sulfonylurea and sulfonylurea agonists of the pancreatic KATP channel.
P2860
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P2860
Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity
description
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2006
@ast
im September 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/09/29)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/09/29)
@nl
наукова стаття, опублікована у вересні 2006
@uk
name
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@ast
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@en
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@nl
type
label
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@ast
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@en
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@nl
prefLabel
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@ast
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@en
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@nl
P2093
P2860
P3181
P356
P1476
Inhibition of cyclin-dependent ...... beta cells from glucotoxicity
@en
P2093
J. Michael Rukstalis
Joel F. Habener
Mariano Ubeda
P2860
P304
28858–28864
P3181
P356
10.1074/JBC.M604690200
P407
P577
2006-09-29T00:00:00Z