A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction
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SNX27 mediates PDZ-directed sorting from endosomes to the plasma membraneDeficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C)Shotgun proteomics in neuroscienceRole of the Retromer Complex in Neurodegenerative DiseasesPhosphoinositides in the mammalian endo-lysosomal networkPhosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPasesA molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complexSorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channelsMembrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel functionGIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behaviorMapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.A role for sorting nexin 27 in AMPA receptor trafficking.Evolutionarily conserved bias of amino-acid usage refines the definition of PDZ-binding motif.Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling.Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs.Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold librariesGlutamine synthetase stability and subcellular distribution in astrocytes are regulated by γ-aminobutyric type B receptors.SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cellsThe role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channelsEmerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junctionSorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins.Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.A C-terminal PDZ binding domain modulates the function and localization of Kv1.3 channelsThe role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.Sex differences in GABA(B)R-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex.Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine NeuronsG Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 Knock-Out Mice Show Enhanced Ethanol Reward
P2860
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P2860
A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction
description
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Oktober 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/10/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/10/01)
@nl
наукова стаття, опублікована в жовтні 2007
@uk
مقالة علمية (نشرت في أكتوبر 2007)
@ar
name
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@ast
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@en
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@nl
type
label
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@ast
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@en
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@nl
prefLabel
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@ast
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@en
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@nl
P2093
P356
P1433
P1476
A unique sorting nexin regulat ...... s via a PDZ domain interaction
@en
P2093
Carlos M. Arias
Christine Arrabit
Ian McLeod
John R. Yates
Joshua Tan
Marie-Louise Lunn
Paul A. Slesinger
Paul E. Sawchenko
Rounak Nassirpour
P2888
P304
P356
10.1038/NN1953
P407
P577
2007-10-01T00:00:00Z