Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin
about
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetamAbnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosisThe iTRAPs: Guardians of Synaptic Vesicle Cargo Retrieval During EndocytosisGlycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FThe synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surfaceLevetiracetam reverses synaptic deficits produced by overexpression of SV2ADelineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagminSV2B regulates synaptotagmin 1 by direct interactionModulation of the conformational state of the SV2A protein by an allosteric mechanism as evidenced by ligand binding assays.Interaural timing difference circuits in the auditory brainstem of the emu (Dromaius novaehollandiae).Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafishIdentification of two cDNAs encoding synaptic vesicle protein 2 (SV2)-like proteins from epithelial tissues in the cat flea, Ctenocephalides felis.Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.SVOP is a nucleotide binding protein.Protein-protein interactions and protein modules in the control of neurotransmitter release.Puzzling Out Synaptic Vesicle 2 Family Members Functions.Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.Cotrafficking of SV2 and synaptotagmin at the synapse.Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.A conserved mechanism of synaptogyrin localization.Kisspeptins modulate the biology of multiple populations of gonadotropin-releasing hormone neurons during embryogenesis and adulthood in zebrafish (Danio rerio).SV2 acts via presynaptic calcium to regulate neurotransmitter release.Molecular mechanisms of neurotransmitter release.Role of synaptotagmin in Ca2+-triggered exocytosis.Protein quantification at the single vesicle level reveals that a subset of synaptic vesicle proteins are trafficked with high precisionLoss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.Expression of SV2 isoforms during rodent brain development.Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam.Identification of the antiepileptic racetam binding site in the synaptic vesicle protein 2A by molecular dynamics and docking simulations.Overlapping functions of stonin 2 and SV2 in sorting of the calcium sensor synaptotagmin 1 to synaptic vesiclesThe tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis.Interaction of the synprint site of N-type Ca2+ channels with the C2B domain of synaptotagmin I.Role of DHA in aging-related changes in mouse brain synaptic plasma membrane proteome.Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function.Correlation of non-uniform protein expression with variation in transmitter release probability.Association of botulinum neurotoxins with synaptic vesicle protein complexes.
P2860
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P2860
Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin
description
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im November 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/11/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/11/01)
@nl
наукова стаття, опублікована в листопаді 1996
@uk
name
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@ast
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@en
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@nl
type
label
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@ast
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@en
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@nl
prefLabel
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@ast
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@en
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@nl
P2093
P2860
P356
P1476
Isoform-specific, calcium-regu ...... proteins SV2 and synaptotagmin
@en
P2093
A. E. Schivell
R. H. Batchelor
S. M. Bajjalieh
P2860
P304
27770–27775
P356
10.1074/JBC.271.44.27770
P407
P577
1996-11-01T00:00:00Z