Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
about
A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPasesPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityStructure-function studies of the G-domain from human gem, a novel small G-proteinIdentification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinRegulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesThe GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathwayMolecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteinsActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαNerve growth factor-dependent activation of the small GTPase RinRLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-betaThe ß subunit of voltage-gated Ca2+ channelsA loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexityAncient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split.Human RAS superfamily proteins and related GTPases.Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.Unexpected cross talk: small GTPase regulation of calcium channel trafficking.Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivationPlasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currentsIsolation and molecular characterization of Rem2 isoforms in the rainbow trout (Oncorhynchus mykiss): Tissue and central nervous system expressionDose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPasesThe RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia.CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity.Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdalaEngineering proteins for custom inhibition of Ca(V) channels.Rem2 in the bullfrog (Rana catesbeiana): Patterns of expression within the central nervous system and brain expression at different ontogenetic stagesRegulation of voltage-dependent calcium channels by RGK proteins.An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.The GTPase Rem2 regulates synapse development and dendritic morphologyLocalization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss).Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9.Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.Rad and Rem are non-canonical G-proteins with respect to the regulatory role of guanine nucleotide binding in Ca(V)1.2 channel regulation.Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.The small GTPase RSG1 controls a final step in primary cilia initiation.
P2860
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P2860
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
description
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
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im April 2000 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2000/04/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/04/01)
@nl
наукова стаття, опублікована у квітні 2000
@uk
مقالة علمية (نشرت في أبريل 2000)
@ar
name
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
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Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@en
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@nl
type
label
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@ast
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@en
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@nl
prefLabel
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@ast
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@en
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@nl
P2093
P2860
P3181
P1433
P1476
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases
@en
P2093
B. S. Finlin
D. A. Andres
K. Kadono-Okuda
P2860
P304
P3181
P356
10.1042/0264-6021:3470223
P407
P478
P577
2000-04-01T00:00:00Z