Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
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Modulation of actin dynamics by Rac1 to target cognitive functionThe role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment.Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.Neuronal mechanisms and circuits underlying repetitive behaviors in mouse models of autism spectrum disorderCommon mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disordersShank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminalsReversal of social deficits by subchronic oxytocin in two autism mouse models.Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient ratMolecular handoffs in nitrergic neurotransmissionIntegrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders.Effects of trace metal profiles characteristic for autism on synapses in cultured neuronsSynergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autismDbo/Henji Modulates Synaptic dPAK to Gate Glutamate Receptor Abundance and Postsynaptic Response.Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapsesSpecific Roles of NMDA Receptor Subunits in Mental Disorders.Glutamatergic candidate genes in autism spectrum disorder: an overview.The role of F-actin in modulating Clathrin-mediated endocytosis: Lessons from neurons in health and neuropsychiatric disorder.Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke.Novel functions for ADF/cofilin in excitatory synapses - lessons from gene-targeted miceAutism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin RegulatorsStem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development.Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function.Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model.Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer's Disease.Impaired Object Recognition but Normal Social Behavior and Ultrasonic Communication in Cofilin1 Mutant Mice.Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review.Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.Emerging role of synaptic actin-regulatory pathway in the pathophysiology of mood disordersDietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Exon 13-16 Mutant Mice
P2860
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P2860
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
description
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im Oktober 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/10/02)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/10/02)
@nl
наукова стаття, опублікована в жовтні 2013
@uk
مقالة علمية (نشرت في 2-10-2013)
@ar
name
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@ast
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@en
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@nl
type
label
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@ast
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@en
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@nl
prefLabel
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@ast
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@en
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@nl
P2093
P2860
P3181
P1476
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism
@en
P2093
Katharine R Smith
Lara J Duffney
Wenhua Liu
P2860
P304
15767-15778
P3181
P356
10.1523/JNEUROSCI.1175-13.2013
P407
P577
2013-10-01T00:00:00Z