Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold
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Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active ZonePhosphoinositides: tiny lipids with giant impact on cell regulationPhosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentStructural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosisPhospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development.SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.A novel missense mutation in the C2C domain of otoferlin causes profound hearing impairment in an Omani family with auditory neuropathy.Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowthComparative gene identification 58/α/β hydrolase domain 5 lacks lysophosphatidic acid acyltransferase activityMicroscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsNegative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Physical chemistry and membrane properties of two phosphatidylinositol bisphosphate isomersComplexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Cell healing: Calcium, repair and regeneration.Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization.Calcium Directly Regulates Phosphatidylinositol 4,5-Bisphosphate Headgroup Conformation and Recognition.The cortical acto-Myosin network: from diffusion barrier to functional gateway in the transport of neurosecretory vesicles to the plasma membrane.Role of calcium in membrane interactions by PI(4,5)P₂-binding proteins.PI(4,5)P₂-binding effector proteins for vesicle exocytosis.Translating neuronal activity at the synapse: presynaptic calcium sensors in short-term plasticity.Circular oligomerization is an intrinsic property of synaptotagmin.The Molecules of Sperm Exocytosis.C2-domain containing calcium sensors in neuroendocrine secretion.Quantifying lipid changes in various membrane compartments using lipid binding protein domains.The Mechanisms and Functions of Synaptic Facilitation.Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin.Basic presynaptic functions in hippocampal neurons are not affected by acute or chronic lithium treatment.The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis.Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release.RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.
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P2860
Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold
description
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2012
@ast
im Mai 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/05/11)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/05/11)
@nl
наукова стаття, опублікована в травні 2012
@uk
name
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@ast
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@en
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@nl
type
label
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@ast
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@en
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@nl
prefLabel
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@ast
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@en
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@nl
P2860
P50
P3181
P356
P1476
Phosphatidylinositol 4,5-bisph ...... of synaptotagmin-1 by 40-fold
@en
P2093
Karsten Meyenberg
P2860
P304
16447–16453
P3181
P356
10.1074/JBC.M112.343418
P407
P577
2012-05-11T00:00:00Z