Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
about
Rapamycin and its analogues (rapalogs) for tuberous sclerosis complexThe p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Identification and characterization of the interaction between tuberin and 14-3-3zetaInsulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubesRegulation of TSC2 by 14-3-3 bindingSignaling by target of rapamycin proteins in cell growth controlTuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityEfficacy and safety of sirolimus in lymphangioleiomyomatosis.An emerging role for TOR signaling in mammalian tissue and stem cell physiologyThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthAbnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2AKT/PKB signaling: navigating downstreamTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingRole of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosisBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlNailing down a link between tuberin and renal cystsRapamycin and rapalogs for tuberous sclerosis complexRapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysisOptimizing treatments for lymphangioleiomyomatosisRegulation of mTORC1 by PI3K signalingLymphangioleiomyomatosis: differential diagnosis and optimal managementSex-specific lung diseases: effect of oestrogen on cultured cells and in animal modelsCell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38The tuberin-hamartin complex negatively regulates beta-catenin signaling activityCell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin BPam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complexRegulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independentAssociation of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growthInteraction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathwayMulticenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decreaseFeedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPaseParadoxical effects of rapamycin on experimental house dust mite-induced asthmaTarget of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progressionTOR signaling.mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
P2860
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P2860
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
description
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im August 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/08/23)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/08/23)
@nl
наукова стаття, опублікована в серпні 2002
@uk
name
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@ast
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@en
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@nl
type
label
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@ast
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@en
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@nl
prefLabel
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@ast
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@en
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@nl
P2093
P3181
P356
P1476
Tuberin regulates p70 S6 kinas ...... lymphangioleiomyomatosis (LAM)
@en
P2093
Andrew Eszterhas
Cheryl L. Walker
Daniel Noonan
David J. Kwiatkowski
Deborah S. Hunter
Dmitry A. Goncharov
Elena A. Goncharova
Margaret M. Chou
Marilyn K. Glassberg
Raymond S. Yeung
P304
30958–30967
P3181
P356
10.1074/JBC.M202678200
P407
P577
2002-08-23T00:00:00Z