Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins
about
OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-66-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysisThe Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctionsStructural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensisTranscription Factors in Fungi: TFome Dynamics, Three Major Families, and Dual-Specificity TFsHMMerThread: detecting remote, functional conserved domains in entire genomes by combining relaxed sequence-database searches with fold recognition.Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine.Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.Antiglucocorticoid activity of hepatocyte nuclear factor-6.Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites.Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition.Regulation of cell proliferation and differentiation in the kidney.Onecut transcription factors in development and disease.Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells.Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter.An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors.Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors.HNF-6-independent differentiation of mouse embryonic stem cells into insulin-producing cells.Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription.Hepatocyte nuclear factor-6 stimulates transcription of the alpha-fetoprotein gene and synergizes with the retinoic-acid-receptor-related orphan receptor alpha-4MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis.On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo.Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA.Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.Temporal regulation of enhancer function in intestinal epithelium: a role for Onecut factors.Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse.Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation.
P2860
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P2860
Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins
description
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im Mai 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/05/29)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/05/29)
@nl
наукова стаття, опублікована в травні 1998
@uk
name
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@ast
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@en
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@nl
type
label
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@ast
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@en
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@nl
prefLabel
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@ast
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@en
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@nl
P2093
P2860
P356
P1476
Isoforms of hepatocyte nuclear ...... class of homeodomain proteins
@en
P2093
F. P. Lemaigre
G. G. Rousseau
T. R. Bürglin
V. J. Lannoy
P2860
P304
13552–13562
P356
10.1074/JBC.273.22.13552
P407
P577
1998-05-29T00:00:00Z