Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways
about
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathwayProtein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domainAn amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machineryMEK5/ERK5 pathway: the first fifteen yearsRegulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoformsUbiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1)Renal expression and activity of the germinal center kinase SK2Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tauBMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway.Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells.Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium.Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.Clinical applications of laser scanning cytometry.IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.The many forks in FOXO's road.Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty.Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1SGK3 (CISK) may induce tumor angiogenesis (Hypothesis).The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import proteinThe serum- and glucocorticoid-induced protein kinase-1 (Sgk-1) mitochondria connection: identification of the IF-1 inhibitor of the F(1)F(0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogeSerum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter.Regulation of psychostimulant-induced signaling and gene expression in the striatumGlucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1.Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes.The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells.Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel.An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function.Downregulation of SGK1 by nucleotides in renal tubular epithelial cells.Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells.The N-terminus of the serum- and glucocorticoid-inducible kinase Sgk1 specifies mitochondrial localization and rapid turnover.Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport.The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors.Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.
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Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways
description
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im März 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/03/12)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/03/12)
@nl
наукова стаття, опублікована в березні 1999
@uk
name
Cell cycle and hormonal contro ...... rative cell signaling pathways
@ast
Cell cycle and hormonal contro ...... rative cell signaling pathways
@en
Cell cycle and hormonal contro ...... rative cell signaling pathways
@nl
type
label
Cell cycle and hormonal contro ...... rative cell signaling pathways
@ast
Cell cycle and hormonal contro ...... rative cell signaling pathways
@en
Cell cycle and hormonal contro ...... rative cell signaling pathways
@nl
prefLabel
Cell cycle and hormonal contro ...... rative cell signaling pathways
@ast
Cell cycle and hormonal contro ...... rative cell signaling pathways
@en
Cell cycle and hormonal contro ...... rative cell signaling pathways
@nl
P2093
P2860
P356
P1476
Cell cycle and hormonal contro ...... rative cell signaling pathways
@en
P2093
G. L. Firestone
G. W. Aponte
S. H. Tran
P2860
P304
P356
10.1074/JBC.274.11.7253
P407
P577
1999-03-12T00:00:00Z