Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain
about
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesisHuman homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycansIdentification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase familyGolgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilotalpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-GlcStructure-based design of beta 1,4-galactosyltransferase I (beta 4Gal-T1) with equally efficient N-acetylgalactosaminyltransferase activity: point mutation broadens beta 4Gal-T1 donor specificityGlycosphingolipid-Protein Interaction in Signal TransductionRole of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and CancerGalactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cellsChinese hamster ovary (CHO) cells may express six beta 4-galactosyltransferases (beta 4GalTs). Consequences of the loss of functional beta 4GalT-1, beta 4GalT-6, or both in CHO glycosylation mutants.Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.The organizing potential of sphingolipids in intracellular membrane transport.Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway.Harnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders.Structure and function of beta -1,4-galactosyltransferaseCloning and transcriptional regulation of genes responsible for synthesis of gangliosides.Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.Sphingolipids: the nexus between Gaucher disease and insulin resistance.Glycosphingolipids: synthesis and functions.How Do Gangliosides Regulate RTKs Signaling?Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.Challenge to the suppression of tumor growth by the β4-galactosyltransferase genes.Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against CancerGanglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms.Gene expression levels of β4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells.GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells.Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis.Identification and characterization of a Drosophila melanogaster ortholog of human beta1,4-galactosyltransferase VII.Stage- and tissue-specific expression of a beta-1,4-galactosyltransferase in the embryonic epidermis.Effect of glycosphingolipids on osteoclastogenesis and osteolytic bone diseases.Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis.Improving solubility of catalytic domain of human beta-1,4-galactosyltransferase 1 through rationally designed amino acid replacements.Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis.Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel beta-1,4-galactosyltransferase IV and beta-1,3-n-acetylglucosaminyltransferase."Add-on" domains of Drosophila β1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein.The acceptor substrate specificity of human beta4-galactosyltransferase V indicates its potential function in O-glycosylation.Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development.Accumulation of unusual gangliosides G(Q3) and G(P3) in breast cancer cells expressing the G(D3) synthase.Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo.
P2860
Q22004161-4CAB2F5C-037C-4C23-B500-D48C61164053Q22010476-1C7C34AE-2315-4CC6-9937-0158670D7044Q24290427-46F96D76-61C2-4857-8F4F-2FB252456B20Q24652891-E7EE4E77-EA5B-42C3-9A6B-901717A2FC30Q27633866-8BC1BD61-26C0-4FDD-A8D8-D4F3AC5C4DA2Q27638603-8E992A4C-5D74-4B69-A439-A4CD6C91F967Q28072827-5CEBB7C1-B123-4CBC-B385-A6A9893B4342Q28077907-B54644D4-1110-4737-915C-CA4DEBEE05ADQ28190501-8B28D3BA-9393-4EA5-8A4A-628E4E6C30E5Q30984805-FF3A1B15-9A13-4525-ABE1-D1790EB966C4Q31123872-243EF181-D316-40BB-9869-11CF632A9140Q34388106-028EDEA7-D201-4990-B31D-560561110986Q35144819-B813996F-8D4D-4945-A83C-03B9217E3E60Q35149929-26A5811C-C5CD-42E6-86AD-7A464AA3C245Q36627413-C96DB119-9718-482B-90E3-C2B18C207088Q37130704-CEAD9F01-50C5-4117-B9A9-5FFB59A3CD36Q37549241-32F0153E-65B3-406B-A6FF-49F80193BF21Q37799400-B0174337-B7BA-4AEF-B894-89659F1B9E41Q38155963-1F94684B-92AE-4D41-A751-8C77B36589C6Q38202831-94D838A9-C208-43F0-BD98-C654691D91A1Q38266425-066C0E3E-07C6-49BB-A422-4FEE21032402Q38368044-74B7D811-4D8D-4D23-8270-809373C015BDQ38544783-016891B4-EC30-4D50-90E5-F16621E65C73Q38598747-8F07CBD3-4AA9-4F5F-9AF6-0532EC047B24Q39013293-7EAA2CD4-9093-4782-A942-CFAEA58CED91Q39553492-68FC9FF4-35A6-4B32-B6CC-E290797A0B9DQ39634668-5E56680F-E4F1-4AEA-847B-B57C2AF64D77Q40384285-61B49347-5030-40A6-86C1-3F67D8BDA1EEQ40768422-40701D32-E2DD-4433-A761-61607D2FC007Q42288514-12FE2A78-0BDB-4807-91D2-0487C68015D1Q42682066-9B612C09-B193-4705-A0CA-C3668751BBC1Q42811941-B610C61B-1F84-4F2F-A082-86412BF98A6AQ43698096-93ED3C8B-A3E2-49B1-8888-4AB0C30BD22DQ44127966-E59D4A02-2F56-4360-8723-E68125E4AC00Q46525727-FC4E6D61-40AD-4F76-AA30-8D7415EE2178Q46750623-AE335788-9EBC-48FE-B81F-2D65B4908E5FQ48197881-E3076029-C53F-4560-8DBC-7F23084EF7A6Q48386369-B1468F37-0EA7-48AF-BF22-F96C1918B9E7Q48412125-DFBE230F-6E73-4A92-AC8E-B01818D2731BQ51820931-9555CDB6-AE2E-423A-98F5-686FB8419896
P2860
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain
description
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1998
@ast
im Mai 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/05/29)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/05/29)
@nl
наукова стаття, опублікована в травні 1998
@uk
name
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@ast
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@en
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@nl
type
label
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@ast
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@en
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@nl
prefLabel
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@ast
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@en
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@nl
P2093
P2860
P921
P3181
P356
P1476
Purification, cDNA cloning, an ...... osyltransferase from rat brain
@en
P2093
E. Wakisaka
G. Imokawa
M. Hattori
M. Takizawa
N. Yoshizuka
P2860
P304
13570–13577
P3181
P356
10.1074/JBC.273.22.13570
P407
P50
P577
1998-05-29T00:00:00Z