Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
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beta-Amyloid degradation and Alzheimer's diseaseAlternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondriaA capillary electrophoresis method for evaluation of Abeta proteolysis in vitroMolecular basis for the thiol sensitivity of insulin-degrading enzymeInsulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleA ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.Peroxisomes in brain development and functionThe roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer diseaseAlzheimer's Disease: Mechanism and Approach to Cell TherapyDiverse molecular targets for therapeutic strategies in Alzheimer's diseaseA window into the heterogeneity of human cerebrospinal fluid Aβ peptidesAberrant insulin signaling in Alzheimer's disease: current knowledgeCognitive dysfunction and diabetes mellitusHeterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir.Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid.Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's diseaseMetals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer diseaseNeuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation.Effect of rosiglitazone on amyloid precursor protein processing and Aβ clearance in streptozotocin-induced rat model of Alzheimer's disease.The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.Aggregation of vascular risk factors and risk of incident Alzheimer disease.Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme.Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brainProtein aggregates and dementia: is there a common toxicity?Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?A summary risk score for the prediction of Alzheimer disease in elderly personsAmyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.Evidence for defective retinoid transport and function in late onset Alzheimer's diseaseHigh glucose promotes Aβ production by inhibiting APP degradation.Bidirectional metabolic regulation of neurocognitive function.Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivoPartial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise.Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease
P2860
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P2860
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
description
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/03/01)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/03/01)
@nl
наукова стаття, опублікована в березні 2000
@uk
مقالة علمية (نشرت في مارس 2000)
@ar
name
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@ast
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@en
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@nl
type
label
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@ast
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@en
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@nl
prefLabel
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@ast
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@en
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@nl
P2093
P921
P3181
P1476
Neurons regulate extracellular ...... is by insulin-degrading enzyme
@en
P2093
D. Hartley
D. J. Selkoe
K. Vekrellis
M. R. Rosner
V. Chesneau
P304
P3181
P356
10.1016/S0197-4580(00)82319-2
P407
P577
2000-03-01T00:00:00Z