Paradoxical reduction of synaptic inhibition by vigabatrin
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Molecular targets for antiepileptic drug developmentMechanisms of Action of Antiseizure Drugs and the Ketogenic DietVigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complexIn the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cellsGABA regulates synaptic integration of newly generated neurons in the adult brain.Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.Modulation of spontaneous and GABA-evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A.Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus.Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity.Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptorsDynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore.Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why?GABAA receptors at hippocampal mossy fibers.Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex.Gamma-vinyl GABA increases nonvesicular release of GABA and glutamate in the nucleus accumbens in rats via action on anion channels and GABA transporters.Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis.Dynamic functions of GABA signaling during granule cell maturation.Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital.GABA-independent GABAA receptor openings maintain tonic currents.Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1.Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels.Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release.GABAB receptor modulation of rapid inhibitory and excitatory neurotransmission from subfornical organ and other afferents to median preoptic nucleus neurons.Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.GABAergic signaling to newborn neurons in dentate gyrus.GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus.Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons.The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters.Transmitter metabolism as a mechanism of synaptic plasticity: a modeling study.GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA receptors
P2860
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P2860
Paradoxical reduction of synaptic inhibition by vigabatrin
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2001/08/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/01)
@nl
наукова стаття, опублікована в серпні 2001
@uk
مقالة علمية (نشرت في أغسطس 2001)
@ar
name
Paradoxical reduction of synaptic inhibition by vigabatrin
@ast
Paradoxical reduction of synaptic inhibition by vigabatrin
@en
Paradoxical reduction of synaptic inhibition by vigabatrin
@nl
type
label
Paradoxical reduction of synaptic inhibition by vigabatrin
@ast
Paradoxical reduction of synaptic inhibition by vigabatrin
@en
Paradoxical reduction of synaptic inhibition by vigabatrin
@nl
prefLabel
Paradoxical reduction of synaptic inhibition by vigabatrin
@ast
Paradoxical reduction of synaptic inhibition by vigabatrin
@en
Paradoxical reduction of synaptic inhibition by vigabatrin
@nl
P356
P1476
Paradoxical reduction of synaptic inhibition by vigabatrin
@en
P2093
G. L. Westbrook
L. S. Overstreet
P304
P356
10.1152/JN.2001.86.2.596
P407
P577
2001-08-01T00:00:00Z